国产精品亚洲精品日韩己满十八小,老司机91精品网站在线观看,欧美成人综合视频

<fieldset id="82iwc"></fieldset>

<fieldset id="82iwc"></fieldset>

<tfoot id="82iwc"></tfoot>

<del id="82iwc"></del>

成骨相關轉錄因子抗體

產品貨號：

BN42187R
中文名稱：

成骨相關轉錄因子抗體
英文名稱：

Rabbit anti-Osterix Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42187R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN42187R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	Osterix
中文名稱	成骨相關轉錄因子抗體
別名	Osterix; MGC126598; Osx; Sp 7; Sp7; Sp7 transcription factor; Transcription factor Sp7; Zinc finger protein osterix; SP7_HUMAN.

研究領域	細胞生物染色質和核信號信號轉導干細胞轉錄調節因子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	45kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Osterix:331-431/431
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] Function: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Subunit: Interacts with NO66; the interaction is direct and inhibits transcription activator activity. Subcellular Location: Nucleus. Tissue Specificity: Osteoblast/chondrocyte specific. DISEASE: Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. SWISS: Q8TDD2 Gene ID: 121340 Database links: Entrez Gene: 121340 Human Entrez Gene: 170574 Mouse Entrez Gene: 300260 Rat Omim: 606633 Human SwissProt: Q8TDD2 Human SwissProt: Q5RM08 Mouse SwissProt: Q8VI67 Mouse SwissProt: Q6IMK1 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Osterix成骨相關轉錄因子是一種具有鋅指基序結構域的轉錄因子，在體內的表達對成骨細胞具有特異性。該蛋白只在發育的骨組織中特異性表達，是成骨細胞分化和骨形成過程中所必需的轉錄因子。骨髓基質干細胞分化為表達典型的成骨性標志基因的成骨細胞需要OSX的調控。