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    首頁>>免疫學>>一抗>>白介素1β/IL-1β抗體
    白介素1β/IL-1β抗體
    • 產品貨號:
      BN42184R
    • 中文名稱:
      白介素1β/IL-1β抗體
    • 英文名稱:
      Rabbit anti-IL-1 Beta Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN42184R-50ul

      50ul

      ¥1486.00

      交叉反應:Rat,Mouse,Human 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN42184R-100ul

      100ul

      ¥2360.00

      交叉反應:Rat,Mouse,Human 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN42184R-200ul

      200ul

      ¥3490.00

      交叉反應:Rat,Mouse,Human 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱IL-1 Beta
    中文名稱白介素1β/IL-1β抗體
    別    名Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro interleukin 1 beta; IL1B_HUMAN; Interleukin-1 beta; IL-1 beta.  


    研究領域細胞生物  免疫學  糖蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量17/32kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human IL-1beta:101-200/269 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

    Function:
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

    Subunit:
    Monomer.

    Subcellular Location:
    Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

    Similarity:
    Belongs to the IL-1 family.

    SWISS:
    P01584

    Gene ID:
    3553

    Database links:

    Entrez Gene: 3553 Human

    Entrez Gene: 16176 Mouse

    Entrez Gene: 24494 Rat

    Omim: 147720 Human

    SwissProt: P01584 Human

    SwissProt: P10749 Mouse

    SwissProt: Q63264 Rat

    Unigene: 126256 Human

    Unigene: 222830 Mouse

    Unigene: 9869 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    生長因子和激素( Growth Factor and Hormones)
    IL-1β是一種糖蛋白,它既可誘導急性期時相關蛋白的產生,也是β細胞終末分化并分泌抗體的必需因子,在免疫調節中發揮重要做 用。
    IL-1β前體在細胞內合成后被酶剪切為成熟形態后排出到細胞外,IL-1β的前體有153個氨基酸。成熟形態有116個氨基酸。
















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