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叉頭蛋白P3重組兔單克隆抗體

產品貨號：

BN42081R
中文名稱：

叉頭蛋白P3重組兔單克隆抗體
英文名稱：

Rabbit anti-FOXP3 Monoclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42081R-50ul

50ul

￥2020.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt
BN42081R-100ul

100ul

￥3240.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt

產品描述

英文名稱	FOXP3
中文名稱	叉頭蛋白P3重組兔單克隆抗體
別名	AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.
研究領域	轉錄調節因子
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	12B1
交叉反應	Human,
產品應用	WB=1:500-2000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 Flow-Cyt=2ug/Test ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	47kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human FOXP3 protein, around C-terminal 150aa:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Probable transcription factor. Plays a critical role in the control of immune response. Subunit: Interacts with IKZF3. Subcellular Location: Nucleus (Potential). Post-translational modifications: Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1. DISEASE: Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. SWISS: Q9BZS1 Gene ID: 50943 Database links: Entrez Gene: 50943 Human Entrez Gene: 20371 Mouse Entrez Gene: 317382 Rat Omim: 300292 Human SwissProt: Q9BZS1 Human SwissProt: Q99JB6 Mouse SwissProt: D3ZKI1 Rat Unigene: 247700 Human Unigene: 182291 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.