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14-3-3蛋白zeta/delta單克隆抗體

產(chǎn)品貨號(hào)：

BN42066M
中文名稱：

14-3-3蛋白zeta/delta單克隆抗體
英文名稱：

Mouse anti-YWHAZ Monoclonal antibody
品牌：

Biorigin

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BN42066M-50ul

50ul

￥2020.00

交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF
BN42066M-100ul

100ul

￥3240.00

交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱	YWHAZ
中文名稱	14-3-3蛋白zeta/delta單克隆抗體
別名	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide; Protein Kinase C Inhibitor Protein 1; 14-3-3 Delta; 14-3-3 Zeta; KCIP-1; Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide; 14-3-3 Protein/Cytosolic Phospholipase A2; Protein Kinase C Inhibitor Protein-1; Epididymis Secretory Protein Li 93; Epididymis Secretory Protein Li 3; Epididymis Luminal Protein 4; 14-3-3 Protein Zeta/Delta; Phospholipase A2; 14-3-3-Zeta; HEL-S-93; HEL-S-3; YWHAD;
研究領(lǐng)域	細(xì)胞生物細(xì)胞凋亡
抗體來源	Mouse
克隆類型	Monoclonal
克隆號(hào)	1B6
交叉反應(yīng)	Human, Rat, (predicted: Mouse, )
產(chǎn)品應(yīng)用	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	27kDa
細(xì)胞定位	細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human YWHAZ protein:
亞型	IgG2b
純化方法	affinity purified by Protein G
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Subunit: Interacts with CDK16 and BSPRY. Interacts with WEE1 (C-terminal). Interacts with SAMSN1. Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways. Subcellular Location: Cytoplasm. Post-translational modifications: The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. Similarity: Belongs to the 14-3-3 family. SWISS: P63104 Gene ID: 7534 Database links: Entrez Gene: 7534 Human Entrez Gene: 22631 Mouse Entrez Gene: 25578 Rat Omim: 601288 Human SwissProt: P63104 Human SwissProt: P63101 Mouse SwissProt: P63102 Rat Unigene: 492407 Human Unigene: 3360 Mouse Unigene: 465895 Mouse Unigene: 1292 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.