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乙酰化微管蛋白α/Tubulin α/α-tubulin單克隆抗體

產品貨號：

BN42056M
中文名稱：

乙酰化微管蛋白α/Tubulin α/α-tubulin單克隆抗體
英文名稱：

Mouse anti-alpha Tubulin (Acetyl Lys40) Monoclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42056M-50ul

50ul

￥1688.00

交叉反應：Human,Mouse,Zebrafish(predicted:Rat) 推薦應用：WB,ELISA
BN42056M-100ul

100ul

￥2470.00

交叉反應：Human,Mouse,Zebrafish(predicted:Rat) 推薦應用：WB,ELISA

產品描述

英文名稱	alpha Tubulin (Acetyl Lys40)
中文名稱	乙酰化微管蛋白α/Tubulin α/α-tubulin單克隆抗體
別名	Alpha tubulin 1; Alpha-tubulin 1; Detyrosinated alpha Tubulin; FLJ30169; H2 alpha; TBA4A_HUMAN; TBA1A_HUMAN; TBA1B_HUMAN; Testis specific alpha tubulin; Testis-specific alpha-tubulin; TUBA 4A; TUBA1; Tuba4a; Tubulin alpha 1 (testis specific); Tubulin alpha 1; Tubulin alpha 1 chain; Tubulin alpha 4a; Tubulin alpha 4A chain; Tubulin alpha-1 chain; Tubulin alpha-4A chain; Tubulin H2 alpha; Tubulin H2-alpha; TUBA4A.
產品類型	乙酰化抗體
研究領域	細胞生物信號轉導細胞骨架
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	6B5
交叉反應	Human, Mouse, (predicted: Rat, Danio rerio,)
產品應用	WB=1:500-1000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	50kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised acetylpeptide derived from human alpha Tubulin around the acetylation site of Acetyl Lys40:SD(Ac-K)TI
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Widely expressed. Overexpressed in Platelet, Brain, and Frontal cortex Post-translational modifications: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity). Similarity: Belongs to the tubulin family. SWISS: P68366 Gene ID: 7277 Database links: Entrez Gene: 7277 Human Entrez Gene: 22145 Mouse Entrez Gene: 316531 Rat Omim: 191110 Human SwissProt: P68366 Human SwissProt: P68368 Mouse SwissProt: Q5XIF6 Rat Unigene: 75318 Human Unigene: 1155 Mouse Unigene: 92961 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.