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Bcl-2同源結(jié)構(gòu)域蛋白單克隆抗體

產(chǎn)品貨號：

BN42042M
中文名稱：

Bcl-2同源結(jié)構(gòu)域蛋白單克隆抗體
英文名稱：

Mouse anti-Beclin 1 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42042M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
BN42042M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	Beclin 1
中文名稱	自噬效應(yīng)蛋白Beclin 1單克隆抗體
別名	Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.
研究領(lǐng)域	腫瘤免疫學(xué) 神經(jīng)生物學(xué) 細胞凋亡
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	7B12
交叉反應(yīng)	Human, Mouse, Rat,
產(chǎn)品應(yīng)用	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	50kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Beclin 1:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Subunit: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB. Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1. Subcellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes. Similarity: Belongs to the beclin family. SWISS: Q14457 Gene ID: 8678 Database links: Entrez Gene: 8678 Human Entrez Gene: 56208 Mouse Entrez Gene: 114558 Rat Omim: 604378 Human SwissProt: Q14457 Human SwissProt: O88597 Mouse SwissProt: Q91XJ1 Rat Unigene: 716464 Human Unigene: 178947 Mouse Unigene: 2776 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BECN1是一種分子質(zhì)量為60KDa的蛋白質(zhì), 它能與細胞凋亡抑制劑Bcl-2相互作用, 減少中樞神經(jīng)系統(tǒng)的凋亡，參與PI3K復(fù)合物的組成和自噬體的形成。主要表達在胞質(zhì)。抑癌基因beclin 1通過自噬作用來調(diào)節(jié)細胞生長。