最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>一氧化氮合成酶-3(內皮型)單克隆抗體
    一氧化氮合成酶-3(內皮型)單克隆抗體
    • 產品貨號:
      BN42006M
    • 中文名稱:
      一氧化氮合成酶-3(內皮型)單克隆抗體
    • 英文名稱:
      Mouse anti-eNOS Monoclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN42006M-50ul

      50ul

      ¥1486.00

      交叉反應:Human,Mouse,Rat 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN42006M-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse,Rat 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱eNOS
    中文名稱一氧化氮合成酶-3(內皮型)單克隆抗體
    別    名NOS-3; cNOS; Constitutive NOS; EC NOS; ecNOS; Endothelial nitric oxidase synthase; Endothelial nitric oxide synthase; Endothelial nitric oxide synthase 3; Endothelial NOS; Nitric oxide synthase 3 (endothelial cell); Nitric oxide synthase 3; Nitric oxide synthase 3 endothelial cell; Nitric oxide synthase endothelial; nitric oxide synthase, endothelial; NOS 3; NOS III; NOS type III; NOS3; NOSIII; NOS3_HUMAN.  
    研究領域細胞生物  神經生物學  信號轉導  合成與降解  內皮細胞  
    抗體來源Mouse
    克隆類型Monoclonal
    克 隆 號8G1
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量133kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from mouse eNOS around the phosphorylation site of Ser113: 
    亞    型IgG
    純化方法affinity purified by Protein G
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Nitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).
    eNOS is a calcium/calmodulin dependent enzyme which undergoes several post translational modifications, including acylation with myristate and palmitate, and phosphorylation on numerous residues. As with the other members of the NOS family, eNOS derives the diffusible multifunctional second messenger NO from L arginine through a series of reactions in which L citrulline is an intermediate. eNOS plays an important role in controlling vascular tone, platelet aggregation, and cardiac myocyte function.

    Function:
    Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
    Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.

    Subunit:
    Homodimer. Interacts with NOSIP and NOSTRIN.

    Subcellular Location:
    Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.

    Tissue Specificity:
    Platelets, placenta, liver and kidney.

    Post-translational modifications:
    Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity. Phosphorylation of Ser-114 by CDK5 reduces activity.

    Similarity:
    Belongs to the NOS family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.

    SWISS:
    P70313

    Gene ID:
    18127

    Database links:

    Entrez Gene: 287024 Cow

    Entrez Gene: 4846 Human

    Entrez Gene: 18127 Mouse

    Entrez Gene: 24600 Rat

    Omim: 163729 Human

    SwissProt: P29473 Cow

    SwissProt: P29474 Human

    SwissProt: P70313 Mouse

    SwissProt: Q62600 Rat

    Unigene: 647092 Human

    Unigene: 258415 Mouse

    Unigene: 44265 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    合成與降解(Synthesis and Degradation)
    催化生物體內一氧化氮(NO)生成的酶。分神經型一氧化氮合成的酶(nNOS or NOS-1)、誘導型一氧化氮合成的酶(iNOS or NOS-2)、內皮型一氧化氮合成的酶(eNOS or NOS-3)。此抗體識別分子量為135kDa的內皮型一氧化氮合成的酶。


    亚洲狠狠狠一区二区三区| 亚洲第一区香蕉_国产a| 亚洲精品高清国产麻豆专区| 亚洲韩国精品无码一区二区三区| 亚洲片一区二区三区| 亚洲AV中文无码乱人伦| 伊在人亚洲香蕉精品区麻豆| 国产区图片区小说区亚洲区| 国产成人精品亚洲| 在线91精品亚洲网站精品成人| 亚洲国产成人久久精品软件| 高清在线亚洲精品国产二区| 精品无码专区亚洲| 国产精品亚洲二区在线| 国产亚洲福利精品一区二区| 亚洲国产成人乱码精品女人久久久不卡| 国产精品亚洲五月天高清| 亚洲成片观看四虎永久| 亚洲免费日韩无码系列| 自拍偷自拍亚洲精品被多人伦好爽 | 亚洲欧美日韩自偷自拍| 亚洲av成人片在线观看| 亚洲成AV人在线观看网址| 国产成人精品日本亚洲专区| 亚洲日韩精品无码专区网址| 亚洲AV无码久久| 亚洲视频免费在线播放| 亚洲w码欧洲s码免费| 亚洲一线产品二线产品| 国产精品亚洲а∨无码播放不卡| 亚洲国产精品一区二区九九| 亚洲中文字幕在线第六区| 亚洲av无码片在线播放| 亚洲欧洲春色校园另类小说| 自拍日韩亚洲一区在线| 亚洲AV色无码乱码在线观看| 亚洲伦乱亚洲h视频| 精品国产亚洲一区二区三区| 久久精品亚洲中文字幕无码麻豆| 亚洲人成综合在线播放| 亚洲av无码兔费综合|