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胰島素降解酶單克隆抗體

產品貨號：

BN41995M
中文名稱：

胰島素降解酶單克隆抗體
英文名稱：

Mouse anti-IDE Monoclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41995M-50ul

50ul

￥1486.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN41995M-100ul

100ul

￥2360.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN41995M-200ul

200ul

￥3490.00

交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產品描述

英文名稱	IDE
中文名稱	胰島素降解酶單克隆抗體
別名	BC2; Insulin degrading enzyme; FLJ35968; insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.
研究領域	腫瘤心血管細胞生物免疫學信號轉導生長因子和激素糖尿病
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	5H4
交叉反應	Human,
產品應用	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	117kDa
細胞定位	細胞漿細胞膜細胞外基質
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IDE:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases. Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling. Function: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Subunit: Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus. Subcellular Location: Cytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the peptidase M16 family. SWISS: P14735 Gene ID: 3416 Database links: Entrez Gene: 3416 Human Entrez Gene: 15925 Mouse Entrez Gene: 25700 Rat Omim: 146680 Human SwissProt: P14735 Human SwissProt: Q9JHR7 Mouse SwissProt: P35559 Rat Unigene: 500546 Human Unigene: 28366 Mouse Unigene: 45029 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.