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    首頁>>免疫學>>一抗>>細胞間粘附分子-1單克隆抗體
    細胞間粘附分子-1單克隆抗體
    • 產(chǎn)品貨號:
      BN41973M
    • 中文名稱:
      細胞間粘附分子-1單克隆抗體
    • 英文名稱:
      Mouse anti-ICAM1/CD54 Monoclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41973M-50ul

      50ul

      ¥1486.00

      交叉反應:Human 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN41973M-100ul

      100ul

      ¥2360.00

      交叉反應:Human 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產(chǎn)品描述

    英文名稱ICAM1/CD54
    中文名稱細胞間粘附分子-1單克隆抗體
    別    名BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.  
    研究領域細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞粘附分子  細胞表面分子  糖蛋白  
    抗體來源Mouse
    克隆類型Monoclonal
    克 隆 號4E5
    交叉反應Human, 
    產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量56kDa
    細胞定位細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human ICAM1/CD54:321-420/532 
    亞    型IgG
    純化方法affinity purified by Protein G
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

    Function:
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

    Subunit:
    Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein.

    Post-translational modifications:
    Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

    Similarity:
    Belongs to the immunoglobulin superfamily. ICAM family.
    ontains 5 Ig-like C2-type (immunoglobulin-like) domains.

    SWISS:
    P05362

    Gene ID:
    3383

    Database links:

    Entrez Gene: 3383 Human

    Entrez Gene: 15894 Mouse

    Entrez Gene: 25464 Rat

    Omim: 147840 Human

    Unigene: 643447 Human

    SwissProt: P05362 Human

    SwissProt: P13597 Mouse

    SwissProt: Q00238 Rat

    Unigene: 435508 Mouse

    Unigene: 12 Rat




    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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