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    首頁>>免疫學>>一抗>>內質網核信號轉導蛋白a1抗體
    內質網核信號轉導蛋白a1抗體
    • 產品貨號:
      BN41967R
    • 中文名稱:
      內質網核信號轉導蛋白a1抗體
    • 英文名稱:
      Rabbit anti-IRE1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41967R-50ul

      50ul

      ¥1486.00

      交叉反應:Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    • BN41967R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    • BN41967R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱IRE1
    中文名稱內質網核信號轉導蛋白a1抗體
    別    名IRE1a; Endoplasmic reticulum (ER) to nucleus signalling 1; Endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signaling 1; ERN 1; ERN1; ERN1_HUMAN; hIRE 1p; hIRE1p; Inositol requiring 1; Inositol requiring protein 1; Inositol-requiring protein 1; IRE-1; IRE 1; IRE 1a; IRE 1P; Ire1 alpha; Ire1-alpha; Ire1alpha; IRE1P; MGC163277; Protein kinase/endoribonuclease; Serine/threonine protein kinase/endoribonuclease IRE1.  



    研究領域細胞生物  信號轉導  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量105kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human IRE1a:252-260/977 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

    Function:
    Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

    Subunit:
    Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.

    Subcellular Location:
    Endoplasmic reticulum membrane.

    Tissue Specificity:
    Ubiquitously expressed. High levels observed in pancreatic tissue.

    Post-translational modifications:
    Autophosphorylated.

    Similarity:
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 KEN domain.
    Contains 1 protein kinase domain.

    SWISS:
    O75460

    Gene ID:
    2081

    Database links:

    Entrez Gene: 2081 Human

    Entrez Gene: 78943 Mouse

    Entrez Gene: 498013 Rat

    Omim: 604033 Human

    SwissProt: O75460 Human

    SwissProt: Q9EQY0 Mouse

    Unigene: 133982 Human

    Unigene: 592041 Human

    Unigene: 700027 Human

    Unigene: 20452 Mouse

    Unigene: 340943 Mouse

    Unigene: 226435 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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