最近搜索:細胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁>>免疫學(xué)>>一抗>>FK506結(jié)合蛋白38抗體
    FK506結(jié)合蛋白38抗體
    • 產(chǎn)品貨號:
      BN41960R
    • 中文名稱:
      FK506結(jié)合蛋白38抗體
    • 英文名稱:
      Rabbit anti-FKBP38 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41960R-50ul

      50ul

      ¥1486.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41960R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41960R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

    產(chǎn)品描述

    英文名稱FKBP38
    中文名稱FK506結(jié)合蛋白38抗體
    別    名38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.  
    研究領(lǐng)域細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Horse, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量46kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human FKBP38:255-350/412 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
    Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
    Tissue specificity: Widely expressed. Highest levels seen in the brain.

    Function:
    Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

    Subunit:
    Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.

    Subcellular Location:
    Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity).

    Tissue Specificity:
    Widely expressed. Highest levels seen in the brain.

    Similarity:
    Contains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.

    SWISS:
    Q14318

    Gene ID:
    23770

    Database links:

    Entrez Gene: 23770 Human

    Entrez Gene: 14232 Mouse

    Entrez Gene: 290652 Rat

    Omim: 604840 Human

    SwissProt: Q14318 Human

    SwissProt: O35465 Mouse

    SwissProt: Q3B7U9 Rat

    Unigene: 173464 Human

    Unigene: 141864 Mouse

    Unigene: 99789 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    亚洲AV无码专区亚洲AV伊甸园| 亚洲人成人无码网www电影首页| 西西人体44rt高清亚洲| 红杏亚洲影院一区二区三区| 国产成人 亚洲欧洲| 国产亚洲精品国产福利在线观看| 亚洲AV无码一区二区乱子仑| 亚洲国产成人久久一区二区三区| 亚洲乱妇熟女爽到高潮的片 | 亚洲国产精品福利片在线观看| 亚洲午夜久久久久久久久电影网| 久久伊人亚洲AV无码网站| 国产亚洲老熟女视频| 亚洲日韩一页精品发布| 亚洲精品午夜无码专区| 亚洲成A人片777777| 久久亚洲中文字幕精品有坂深雪| 亚洲综合久久久久久中文字幕| 亚洲精品中文字幕无乱码| 亚洲国产成人手机在线电影bd| 亚洲AV无码一区二区三区人| 中文字幕在线观看亚洲日韩| 亚洲欧美国产精品专区久久| 色窝窝亚洲AV网在线观看| 亚洲国产成人影院播放| 77777亚洲午夜久久多人| 久久久久久久综合日本亚洲| 亚洲欧洲国产精品你懂的| 亚洲网站在线免费观看| 亚洲日本久久一区二区va| 亚洲精品女同中文字幕| 亚洲M码 欧洲S码SSS222| 狠狠亚洲婷婷综合色香五月排名| 亚洲精品成人片在线播放| 久久久久久亚洲精品成人| 亚洲av无码国产综合专区| 亚洲第一综合天堂另类专| 亚洲日本中文字幕天堂网| 国产亚洲人成无码网在线观看| 1区1区3区4区产品亚洲| 亚洲免费福利在线视频|