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BN41932R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
BN41932R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
BN41932R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | CD200 |
| 中文名稱 | 膜糖蛋白CD200抗體 |
| 別 名 | CD200; CD200 antigen; CD200 molecule; MOX1; MOX2; MRC; MRC OX 2 antigen; My033; OX 2; OX 2 membrane glycoprotein precursor; OX-2 membrane glycoprotein; OX2G; OX2G_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)胞表面分子 糖蛋白 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD200:41-140/278 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Subunit: Interacts with CD200R1. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: P41217 Gene ID: 4345 Database links: Entrez Gene: 4345 Human Omim: 155970 Human SwissProt: P41217 Human Unigene: 79015 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD200是Ⅰ型膜糖蛋白，為免疫球蛋白超家族的新成員，廣泛表達(dá)在人類胸腺細(xì)胞、B細(xì)胞、激活的T細(xì)胞、濾泡狀樹突細(xì)胞、神經(jīng)元及血管內(nèi)皮上。可表達(dá)于B細(xì)胞及其增殖性疾病和一部分T細(xì)胞。近年來(lái)研究發(fā)現(xiàn)，CD200與CD200R間的相互作用可以傳遞抑制性信號(hào)減低髓樣細(xì)胞的活性，改變其遷移。CD200在免疫疾病和抑制排斥反應(yīng)中作為一種免疫耐受信號(hào)，它的一些相關(guān)分子在免疫調(diào)節(jié)中也具有一定的作用。 |
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