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    首頁>>免疫學>>一抗>>胞質接頭蛋白Keap1
    胞質接頭蛋白Keap1
    • 產品貨號:
      BN41916R
    • 中文名稱:
      胞質接頭蛋白Keap1
    • 英文名稱:
      Rabbit anti-KEAP1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41916R-50ul

      50ul

      ¥1486.00

      交叉反應:Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    • BN41916R-100ul

      100ul

      ¥2360.00

      交叉反應:Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    • BN41916R-200ul

      200ul

      ¥3490.00

      交叉反應:Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱KEAP1
    中文名稱胞質接頭蛋白Keap1
    別    名Cytosolic inhibitor of Nrf2; INrf 2; INrf2; Keap 1; KEAP1; KEAP1_HUMAN; Kelch like ECH associated protein 1; Kelch like protein 19; Kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132; KLHL 19; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454.  


    研究領域腫瘤  細胞生物  發育生物學  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量69kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human KEAP1:21-120/624 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

    Function:
    Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

    Subunit:
    Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

    Tissue Specificity:
    Broadly expressed, with highest levels in skeletal muscle.

    Similarity:
    Contains 1 BACK (BTB/Kelch associated) domain.
    Contains 1 BTB (POZ) domain.
    Contains 6 Kelch repeats.

    SWISS:
    Q14145

    Gene ID:
    9817

    Database links:

    Entrez Gene: 532791 Cow

    Entrez Gene: 476713 Dog

    Entrez Gene: 9817 Human

    Entrez Gene: 50868 Mouse

    Entrez Gene: 100136900 Pig

    Entrez Gene: 117519 Rat

    Entrez Gene: 321837 Zebrafish

    Omim: 606016 Human

    SwissProt: Q14145 Human

    SwissProt: Q9Z2X8 Mouse

    SwissProt: Q684M4 Pig

    SwissProt: P57790 Rat

    Unigene: 465870 Human

    Unigene: 248266 Mouse

    Unigene: 23467 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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