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    多巴胺受體D2抗體
    • 產品貨號:
      BN41615R
    • 中文名稱:
      多巴胺受體D2抗體
    • 英文名稱:
      Rabbit anti-Dopamine D2 Receptor Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41615R-50ul

      50ul

      ¥1486.00

      交叉反應:Rat(predicted:Human,Mouse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41615R-100ul

      100ul

      ¥2360.00

      交叉反應:Rat(predicted:Human,Mouse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41615R-200ul

      200ul

      ¥3490.00

      交叉反應:Rat(predicted:Human,Mouse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱Dopamine D2 Receptor
    中文名稱多巴胺受體D2抗體
    別    名D2DR; D2 dopamine receptor; D2R; Dopamine receptor D2; Dopamine Receptor D2L; DRD 2; DRD2; DRD2_HUMAN.  
    研究領域腫瘤  細胞生物  免疫學  神經生物學  信號轉導  細胞膜受體  G蛋白偶聯受體  G蛋白信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量51kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human DRD2:201-300/443 <Cytoplasmic>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

    Function:
    This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

    Subcellular Location:
    Cell membrane.

    DISEASE:
    Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family.

    SWISS:
    P14416

    Gene ID:
    1813

    Database links:

    Entrez Gene: 1813 Human

    Entrez Gene: 13489 Mouse

    Entrez Gene: 24318 Rat

    Omim: 126450 Human

    SwissProt: P14416 Human

    SwissProt: P61168 Mouse

    SwissProt: P61169 Rat

    Unigene: 73893 Human

    Unigene: 41970 Mouse

    Unigene: 87299 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    DAD2主要用于多態性與精神分裂癥方面的研究.


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