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    β-酪蛋白抗體
    • 產(chǎn)品貨號:
      BN41610R
    • 中文名稱:
      β-酪蛋白抗體
    • 英文名稱:
      Rabbit anti-Beta-casein Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41610R-50ul

      50ul

      ¥1486.00

      交叉反應(yīng):Human,Cow,Goat(predicted:Sheep) 推薦應(yīng)用:WB,ELISA

    • BN41610R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Cow,Goat(predicted:Sheep) 推薦應(yīng)用:WB,ELISA

    • BN41610R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Cow,Goat(predicted:Sheep) 推薦應(yīng)用:WB,ELISA

    產(chǎn)品描述

    英文名稱Beta-casein
    中文名稱β-酪蛋白抗體
    別    名Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.  
    研究領(lǐng)域細胞生物  免疫學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Cow, Goat,  (predicted: Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量24kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from cow Beta-casein:16-100/224 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

    Function:
    Important role in determination of the surface properties of the casein micelles.
    Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.
    Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.
    Antioxidant peptide has antioxidant activity.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Mammary gland specific. Secreted in milk.

    Similarity:
    Belongs to the beta-casein family.

    SWISS:
    P11839

    Gene ID:
    443391

    Database links:

    Entrez Gene: 1447 Human

    Entrez Gene: 281099 Bovin

    Entrez Gene: 443391 Sheep

    Omim: 115460 Human

    SwissProt: P05814 Human

    SwissProt: P02666 Bovin

    Unigene: 2242 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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