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    首頁>>免疫學>>一抗>>D型-過氧化酶活化增生受體抗體
    D型-過氧化酶活化增生受體抗體
    • 產(chǎn)品貨號:
      BN41520R
    • 中文名稱:
      D型-過氧化酶活化增生受體抗體
    • 英文名稱:
      Rabbit anti-PPAR delta + beta Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41520R-50ul

      50ul

      ¥1486.00

      交叉反應(yīng):Human,Mouse(predicted:Rat) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41520R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Mouse(predicted:Rat) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41520R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Mouse(predicted:Rat) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱PPAR delta + beta
    中文名稱D型-過氧化酶活化增生受體抗體
    別    名PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN.  
    研究領(lǐng)域心血管  免疫學  細胞膜受體  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
    產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量48kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from mouse PPAR-delta:2-100/440 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.

    Function:
    Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Ubiquitous with maximal levels in placenta and skeletal muscle.

    Similarity:
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.

    SWISS:
    P35396

    Gene ID:
    5467

    Database links:

    Entrez Gene: 5467 Human

    Entrez Gene: 19015 Mouse

    Entrez Gene: 25682 Rat

    Omim: 600409 Human

    SwissProt: Q03181 Human

    SwissProt: P35396 Mouse

    Unigene: 696032 Human

    Unigene: 328914 Mouse

    Unigene: 96181 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    類固醇受體(Steroid Receptors)
    研究人員指出該分子的功能,極可能就是阻斷心血管免疫發(fā)炎反應(yīng)的訊號傳遞過程。PPAR-delta基因是控制肌肉發(fā)展的重要基因,在增加老鼠耐力的同時還能幫助它燃燒掉脂肪,研究人員發(fā)現(xiàn),對于與新陳代謝有關(guān)的各項疾病,從心臟病到肥胖癥都有啟發(fā)性的意義,他可以阻止脂肪沉淀在動脈壁上,進而防止動脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動脈硬化和癌癥的發(fā)病。
    在動脈硬化現(xiàn)象發(fā)生的早期,免疫細胞會促使血管慢性的發(fā)炎,因而造成血管不斷地吸收和輸送脂肪,進而導(dǎo)致脂肪的堆積與血管硬化,而PPAR-delta就像警衛(wèi)分子一樣,時時降低發(fā)炎反應(yīng)和抑制動脈硬化斑的形成,因此該分子應(yīng)該是相關(guān)藥物研發(fā),相當值得切入的目標。
    研究人員認為,這個發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。




















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