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    神經生長相關蛋白43抗體
    • 產品貨號:
      BN41497R
    • 中文名稱:
      神經生長相關蛋白43抗體
    • 英文名稱:
      Rabbit anti-GAP43 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41497R-50ul

      50ul

      ¥1486.00

      交叉反應:Rat,Mouse,Human(predicted:Dog,Chicken) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41497R-100ul

      100ul

      ¥2360.00

      交叉反應:Rat,Mouse,Human(predicted:Dog,Chicken) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41497R-200ul

      200ul

      ¥3490.00

      交叉反應:Rat,Mouse,Human(predicted:Dog,Chicken) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱GAP43
    中文名稱神經生長相關蛋白43抗體
    別    名Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.  



    研究領域腫瘤  免疫學  神經生物學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:200-800 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量25/46kDa
    細胞定位細胞漿 細胞膜 細胞外基質 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GAP43:9-100/238 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    Function:
    This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

    Subunit:
    Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

    Subcellular Location:
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

    Post-translational modifications:
    Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
    Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

    Similarity:
    Belongs to the neuromodulin family.
    Contains 1 IQ domain.

    SWISS:
    P06837

    Gene ID:
    2596

    Database links:

    Entrez Gene: 2596 Human

    Entrez Gene: 14432 Mouse

    Entrez Gene: 29423 Rat

    GenBank: NP_002036 Human

    Omim: 162060 Human

    SwissProt: P17677 Human

    SwissProt: P06837 Mouse

    SwissProt: P07936 Rat

    Unigene: 134974 Human

    Unigene: 1222 Mouse

    Unigene: 10928 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    神經生物學相關蛋白(Neurobiology);神經標志物
    GAP43 (Growth associated protein-43)又稱作neuromodulin,是一個軸突膜蛋白,是一種神經特異性的蛋白質,參與神經細胞外生長及突觸發育形成和神經細胞再生。在神經元發育和再生過程中以高水平表達。能調解軸突延伸作用,改變細胞形態。作為細胞內信號,可大大增強與G蛋白偶聯的受體轉運作用。
    神經生長相關蛋白-GAP-43和神經細胞黏附因子(neural cell adhesion molecule,NCAM)與突觸可塑性密切相關.GAP-43是一種神經細胞膜上的特異性磷蛋白,在神經發育和再生過程中呈現高表達,被作為突觸生長的標志物,有稱脊髓生長相關蛋白
    GAP-43與CaM結合,參與G蛋白相互作用,神經遞質的釋放,作用于胞吞/胞吐過程,通過小囊溶合或誘導生長錐和突觸前末端的胞吞促進膜擴展,與海馬長時程增強密切相關.
    神經細胞黏附因子是細胞表面糖蛋白大家族的成員之一,促進軸突生長,對長時記憶的保持有重要影響,同時,GAP-43對其具調節作用,廣泛而深入地研究GAP-43意義深遠。


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