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    孕激素受體抗體
    • 產品貨號:
      BN41487R
    • 中文名稱:
      孕激素受體抗體
    • 英文名稱:
      Rabbit anti-progesterone receptor Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41487R-50ul

      50ul

      ¥1486.00

      交叉反應:Human(predicted:Mouse,Rat,Dog,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41487R-100ul

      100ul

      ¥2360.00

      交叉反應:Human(predicted:Mouse,Rat,Dog,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41487R-200ul

      200ul

      ¥3490.00

      交叉反應:Human(predicted:Mouse,Rat,Dog,Horse,Rabbit) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱progesterone receptor
    中文名稱孕激素受體抗體
    別    名NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.  


    研究領域腫瘤  免疫學  染色質和核信號  信號轉導  生長因子和激素  細胞膜受體  腫瘤細胞生物標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量103kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human progesterone receptor:501-600/933 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

    Function:
    The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
    Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.

    Subunit:
    Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

    Subcellular Location:
    Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.

    Post-translational modifications:
    Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
    Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.

    Similarity:
    Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.

    SWISS:
    P06401

    Gene ID:
    5241

    Database links:

    Entrez Gene: 5241 Human

    Entrez Gene: 18667 Mouse

    Entrez Gene: 100009094 Rabbit

    Entrez Gene: 25154 Rat

    Omim: 607311 Human

    SwissProt: P06401 Human

    SwissProt: Q00175 Mouse

    SwissProt: P06186 Rabbit

    SwissProt: Q63449 Rat

    Unigene: 2905 Human

    Unigene: 32405 Human

    Unigene: 742403 Human

    Unigene: 12798 Mouse

    Unigene: 437703 Mouse

    Unigene: 1947 Rabbit

    Unigene: 10303 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    類固醇受體(Steroid Receptors)孕激素受體是一類位于孕酮靶組織細胞內或細胞表面的特異蛋白質,特異地與孕酮結合,所形成的細胞溶質孕酮-受體復合物隨后與細胞核內的DNA結合,以啟動蛋白質生物合成。孕酮受體有A和B兩種,受雌激素誘導,半壽期很短。


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