最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>腫瘤壞死因子-α/TNFα/TNF-α抗體
    腫瘤壞死因子-α/TNFα/TNF-α抗體
    • 產品貨號:
      BN41479R
    • 中文名稱:
      腫瘤壞死因子-α/TNFα/TNF-α抗體
    • 英文名稱:
      Rabbit anti-TNF alpha Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41479R-50ul

      50ul

      ¥1486.00

      交叉反應:Human(predicted:Dog,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41479R-100ul

      100ul

      ¥2360.00

      交叉反應:Human(predicted:Dog,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41479R-200ul

      200ul

      ¥3490.00

      交叉反應:Human(predicted:Dog,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱TNF alpha
    中文名稱腫瘤壞死因子-α/TNFα/TNF-α抗體
    別    名Tumor necrosis factor-α; TNFalpha; APC1; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNF a; TNF-alpha; TNF; TNF Macrophage Derived; TNF Monocyte Derived; TNF Superfamily Member 2; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor Precurso; Tumour Necrosis Factor Alpha.  



    研究領域腫瘤  心血管  免疫學  信號轉導  細胞凋亡  生長因子和激素  細胞因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Dog, Pig, Horse, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量17/26kDa
    細胞定位細胞膜 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human TNF alpha:86-150/233 <Extracellular>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

    Function:
    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
    The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

    Subunit:
    Homotrimer. Interacts with SPPL2B.

    Subcellular Location:
    Cell membrane; Single-pass type II membrane protein.
    Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.
    Tumor necrosis factor, soluble form: Secreted.
    C-domain 1: Secreted.
    C-domain 2: Secreted.

    Post-translational modifications:
    The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
    The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
    O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.

    DISEASE:
    Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

    Similarity:
    Belongs to the tumor necrosis factor family.

    SWISS:
    P01375

    Gene ID:
    7124

    Database links:

    Entrez Gene: 7124 Human

    Entrez Gene: 21926 Mouse

    Omim: 191160 Human

    SwissProt: P01375 Human

    SwissProt: P06804 Mouse

    Unigene: 241570 Human

    Unigene: 1293 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    生長因子和激素
    腫瘤壞死因子-TNF α是巨嗜細胞感染時或應激情況下自然產生的一種十分活躍的生物活性因子,可能與干擾素協同作用殺傷瘤細胞。






























    image.png

    亚洲中文字幕无码一区二区三区| 亚洲av无码一区二区三区在线播放 | 亚洲欧美日韩久久精品| 亚洲精品在线网站| 日本久久久久亚洲中字幕| 久久久久久亚洲精品| 亚洲av日韩av高潮潮喷无码| 亚洲精品你懂的在线观看| 国产av天堂亚洲国产av天堂 | 91亚洲性爱在线视频| 亚洲国产精品久久丫| 亚洲中文字幕久久精品无码2021| 亚洲成aⅴ人在线观看| 亚洲国产av美女网站| 亚洲av无码专区在线| 亚洲 欧洲 自拍 另类 校园| 亚洲日韩精品国产3区| 亚洲精品中文字幕| 激情小说亚洲色图| 亚洲乱码国产一区网址| 黑人大战亚洲人精品一区| 国产亚洲精品岁国产微拍精品| 亚洲动漫精品无码av天堂| 亚洲一区二区成人| 亚洲婷婷综合色高清在线| 国产精品亚洲片在线va| 亚洲成a∨人片在无码2023| mm1313亚洲精品国产| 国产精品亚洲不卡一区二区三区| 亚洲精品国偷自产在线| 亚洲av成人无码久久精品| 亚洲福利电影一区二区?| 国产成人精品日本亚洲直接| 亚洲精品av无码喷奶水糖心| 偷自拍亚洲视频在线观看| 在线观看亚洲精品国产| 婷婷亚洲久悠悠色悠在线播放| 亚洲精品中文字幕乱码影院| 亚洲中文字幕久久精品无码VA| 午夜在线亚洲男人午在线| 亚洲综合熟女久久久30p|