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    胰島素原抗體
    • 產品貨號:
      BN41475R
    • 中文名稱:
      胰島素原抗體
    • 英文名稱:
      Rabbit anti-Proinsulin Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41475R-50ul

      50ul

      ¥1486.00

      交叉反應:Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,IF,ELISA

    • BN41475R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,IF,ELISA

    • BN41475R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱Proinsulin
    中文名稱胰島素原抗體
    別    名INS_HUMAN; ILPR; INS; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor.  
    研究領域腫瘤  心血管  細胞生物  神經生物學  信號轉導  生長因子和激素  糖尿病  內分泌病  新陳代謝  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量5.8/12kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Insulin:46-59/110 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76% sequence identity and are 50% related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined.

    Function:
    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

    Subunit:
    Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Subcellular Location:
    Secreted.

    DISEASE:
    Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
    Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic dieresis and secondary thirst. These derangements result in long-term complications that
    Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.

    Similarity:
    Belongs to the insulin family.

    SWISS:
    P01308

    Gene ID:
    3630

    Database links:

    Entrez Gene: 3630 Human

    Entrez Gene: 280829 Cow

    Entrez Gene: 16333 Mouse

    Entrez Gene: 16334 Mouse

    Entrez Gene: 24505 Rat

    Entrez Gene: 397415 Pig

    Omim: 176730 Human

    SwissProt: P01308 Human

    SwissProt: P01325 Mouse

    SwissProt: P01322 Rat

    SwissProt: P01315 Pig

    Unigene: 272259 Human





    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    胰島素(Isulin)胰島素抗體是胰島細胞分泌得一種激素,可以減底血糖濃度。此抗體和人胰島素反應,并與大多數哺乳類動物的胰島素有交叉反應,主要用于胰島細胞瘤的功能性研究。




















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