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    首頁>>免疫學>>一抗>>黑色素瘤相關抗原/黑色素-A抗體
    黑色素瘤相關抗原/黑色素-A抗體
    • 產品貨號:
      BN41473R
    • 中文名稱:
      黑色素瘤相關抗原/黑色素-A抗體
    • 英文名稱:
      Rabbit anti-Melan A Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規(guī)格

      售價

      備注

    • BN41473R-50ul

      50ul

      ¥1486.00

      交叉反應:Human 推薦應用:IHC-P,IHC-F,IF,ELISA

    • BN41473R-100ul

      100ul

      ¥2360.00

      交叉反應:Human 推薦應用:IHC-P,IHC-F,IF,ELISA

    • BN41473R-200ul

      200ul

      ¥3490.00

      交叉反應:Human 推薦應用:IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱Melan A
    中文名稱黑色素瘤相關抗原/黑色素-A抗體
    別    名Protein Melan-A; Antigen LB39 AA; MelanA; Melanoma HMB45; Antigen SK29 AA; Antigen SK29-AA; CMM 1; CMM; CMM1; Cutaneous Malignant Melanoma Dysplastic Nevus; DNS; Dysplastic Nevus Syndrome; FAMMM; MART1; melan A; Melan A protein; Melanoma antigen recognized by T-cells 1; MLM; Monophenol monooxygenase; Tumor rejection antigen AB; tyrosinase; Melanoma HMB45; Melanoma; Melan-A; MART-1; MAR1_HUMAN.  
    研究領域腫瘤  細胞生物  免疫學  腫瘤細胞生物標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, 
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量13kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Melan-A:51-118/118 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.

    Function:
    Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

    Subunit:
    Interacts with PMEL. Interacts with GPR143.

    Subcellular Location:
    Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

    Tissue Specificity:
    Expression is restricted to melanoma and melanocyte cell lines and retina.

    Post-translational modifications:
    Acylated.

    SWISS:
    Q16655

    Gene ID:
    2315

    Database links:

    Entrez Gene: 2315 Human

    Omim: 605513 Human

    SwissProt: Q16655 Human

    Unigene: 154069 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    信號中間體(Signaling Intermediates)
    MelanA/MART-1是分化腫瘤抗原類別中具有代表性的成員,它表達于正常的黑素細胞和大多數原發(fā)及轉移的黑色素瘤中,故稱:黑色素瘤相關抗原。

















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