最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>核突觸蛋白-α抗體(N端)
    核突觸蛋白-α抗體(N端)
    • 產品貨號:
      BN41459R
    • 中文名稱:
      核突觸蛋白-α抗體(N端)
    • 英文名稱:
      Rabbit anti-alpha-Synuclein Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41459R-50ul

      50ul

      ¥1486.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN41459R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN41459R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱alpha-Synuclein
    中文名稱核突觸蛋白-α抗體(N端)
    別    名SNCA; SYUA_HUMAN; Alpha synuclein; Alpha-synuclein, isoform NACP140; alpha SYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; Parkinson disease familial 1; Syn; Snca synuclein, alpha (non A4 component of amyloid precursor); Synuclein alpha; Synuclein, alpha (non A4 component of amyloid precursor); Synuclein-α; Synuclein α.   
    研究領域細胞生物  神經生物學  細胞凋亡  Alzheimer's  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量14kDa
    細胞定位細胞核 細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human alpha-Synuclein:51-90/140 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].

    Function:
    May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

    Subunit:
    Soluble monomer which can form filamentous aggregates. Interacts with UCHL1. Interacts with phospholipase D and histones.

    Subcellular Location:
    Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.

    Tissue Specificity:
    Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

    Post-translational modifications:
    Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.
    Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.
    Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).
    Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

    DISEASE:
    Note=Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer disease amyloid plaque, and a major component of Lewy body inclusions. They are also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1.
    Parkinson disease 1 (PARK1) [MIM:168601]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Parkinson disease 4 (PARK4) [MIM:605543]: A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Note=The disease is caused by mutations affecting the gene represented in this entry. [DISEASE] Dementia Lewy body (DLB) [MIM:127750]: A neurodegenerative disorder characterized by mental impairment leading to dementia, parkinsonism, fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease. Note=The disease is caused by mutations affecting the gene represented in this entry.

    Similarity:
    Belongs to the synuclein family.

    SWISS:
    P37840

    Gene ID:
    6622

    Database links:

    Entrez Gene: 6622 Human

    Entrez Gene: 20617 Mouse

    Entrez Gene: 29219 Rat

    Omim: 163890 Human

    SwissProt: P37840 Human

    SwissProt: O55042 Mouse

    SwissProt: P37377 Rat

    Unigene: 21374 Human

    Unigene: 17484 Mouse

    Unigene: 1827 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Synuclein 包括α-Synuclein,β-Synuclein 和γ-Synuclein 是神經細胞中富含的前突觸蛋白。α-Synuclein,Alzheimer’(AD)病淀粉樣蛋白沉積的成份之一,集中分布在神經細胞的包體和突觸。在帕金森病人中發現有α-Synuclein的變異型,而γ-Synuclein與軸突病理學有關。
    此抗體將為Lewy小體癡呆癥、Parkinson癥、AD和其它一些神經性疾病提供有用的病理診斷


    亚洲视频一区网站| 久久夜色精品国产噜噜噜亚洲AV| 亚洲AV色无码乱码在线观看| 亚洲精品无码成人片在线观看| 亚洲专区先锋影音| 亚洲国产精品嫩草影院在线观看 | 亚洲精品黄色视频在线观看免费资源| 亚洲欧美自偷自拍另类视| 亚洲国产综合专区在线电影| 亚洲高清视频一视频二视频三| 亚洲欧洲精品在线| 亚洲人成图片小说网站| 亚洲av综合av一区二区三区| 亚洲成熟丰满熟妇高潮XXXXX| 亚洲国产视频一区| 亚洲伊人久久大香线蕉结合| 久久精品亚洲一区二区| 久久久久亚洲精品天堂久久久久久| 国产亚洲精品bv在线观看| 亚洲国产综合精品中文第一区| 亚洲另类无码专区首页| 亚洲乱妇熟女爽到高潮的片| 亚洲国产精品无码久久久秋霞1| 亚洲成a人无码亚洲成www牛牛| 狼人大香伊蕉国产WWW亚洲 | 国产区图片区小说区亚洲区| 国产成人精品亚洲日本在线| 亚洲综合无码无在线观看| 亚洲妓女综合网99| 久久久久久亚洲精品影院| 亚洲精品色播一区二区| 免费亚洲视频在线观看| 区久久AAA片69亚洲| 亚洲av日韩片在线观看| 久久久青草青青国产亚洲免观 | 亚洲一区二区三区无码中文字幕| 亚洲av无码专区在线播放| 亚洲日韩欧洲乱码AV夜夜摸| 亚洲AV乱码一区二区三区林ゆな| 亚洲毛片在线免费观看| 亚洲国产日韩a在线播放|