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    首頁>>免疫學>>一抗>>ANKLE2蛋白抗體
    ANKLE2蛋白抗體
    • 產品貨號:
      BN41403R
    • 中文名稱:
      ANKLE2蛋白抗體
    • 英文名稱:
      Rabbit anti-ANKLE2 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41403R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse(predicted:Rat,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41403R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse(predicted:Rat,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱ANKLE2
    中文名稱ANKLE2蛋白抗體
    別    名ANKL2_HUMAN; ANKLE 2; ANKLE2; ankyrin repeat and LEM domain containing 2; Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEMD 7; LEMD7.  
    研究領域細胞生物  免疫學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量104kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human ANKLE2:251-350/938 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKLE2 (ankyrin repeat and LEM domain containing 2), also known as LEMD7, is a 938 amino acid single-pass membrane protein containing an ANK repeat and a LEM domain. Exsiting as two isoforms produced by alternative splicing events, the gene encoding ANKLE2 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

    Function:
    Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.

    Subunit:
    Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.

    Subcellular Location:
    Endoplasmic reticulum membrane; Single-pass type III membrane protein.

    Similarity:
    Belongs to the ANKLE2 family.
    Contains 1 ANK repeat.
    Contains 1 LEM domain.

    SWISS:
    Q86XL3

    Gene ID:
    23141

    Database links:

    Entrez Gene: 23141 Human

    SwissProt: Q86XL3 Human

    Unigene: 654628 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications


















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