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    首頁>>免疫學>>一抗>>低密度脂蛋白受體的誘導降解蛋白抗體
    低密度脂蛋白受體的誘導降解蛋白抗體
    • 產品貨號:
      BN41398R
    • 中文名稱:
      低密度脂蛋白受體的誘導降解蛋白抗體
    • 英文名稱:
      Rabbit anti-MYLIP Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41398R-100ul

      100ul

      ¥2360.00

      交叉反應:Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:WB,ELISA

    • BN41398R-200ul

      200ul

      ¥3490.00

      交叉反應:Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:WB,ELISA

    產品描述

    英文名稱MYLIP
    中文名稱低密度脂蛋白受體的誘導降解蛋白抗體
    別    名BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting protein.  
    研究領域心血管  細胞生物  信號轉導  細胞周期蛋白  細胞骨架  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量49kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human MYLIP:51-150/445 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

    Subunit:
    Interacts with myosin regulatory light chain (MRLC) and TMEM4.

    Subcellular Location:
    Cytoplasm.

    Tissue Specificity:
    Ubiquitously expressed.

    Post-translational modifications:
    Autoubiquitinated.

    Similarity:
    Contains 1 FERM domain.
    Contains 1 RING-type zinc finger.

    SWISS:
    Q8WY64

    Gene ID:
    29116

    Database links:

    Entrez Gene: 29116 Human

    Entrez Gene: 218203 Mouse

    Omim: 610082 Human

    SwissProt: Q8WY64 Human

    SwissProt: Q8BM54 Mouse

    Unigene: 484738 Human

    Unigene: 212855 Mouse

    Unigene: 481228 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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