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    肌動(dòng)蛋白結(jié)合蛋白Z盤狀蛋白抗體
    • 產(chǎn)品貨號(hào):
      BN41390R
    • 中文名稱:
      肌動(dòng)蛋白結(jié)合蛋白Z盤狀蛋白抗體
    • 英文名稱:
      Rabbit anti-Nebulette Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN41390R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Mouse(predicted:Human,Rat) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN41390R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Mouse(predicted:Human,Rat) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產(chǎn)品描述

    英文名稱Nebulette
    中文名稱肌動(dòng)蛋白結(jié)合蛋白Z盤狀蛋白抗體
    別    名Actin binding Z disk protein; bA56H7.1; LIM nebulette; LNEBL; NEBL; NEBL_HUMAN.  
    研究領(lǐng)域心血管  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Mouse,  (predicted: Human, Rat, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量116kDa
    細(xì)胞定位細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Nebulette:321-420/1014 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy.
    Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.

    Function:
    Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.

    Subunit:
    Isoform 2 interacts with ZYX (Zyxin).

    Subcellular Location:
    Cytoplasmic.

    Tissue Specificity:
    Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.

    Similarity:
    Contains 23 nebulin repeats.
    Contains 1 SH3 domain.

    SWISS:
    O76041

    Gene ID:
    10529

    Database links:

    Entrez Gene: 10529 Human

    Entrez Gene: 74103 Mouse

    Omim: 605491 Human

    SwissProt: O76041 Human

    SwissProt: Q9DC07 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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