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    FRMPD2抗體
    • 產品貨號:
      BN41360R
    • 中文名稱:
      FRMPD2抗體
    • 英文名稱:
      Rabbit anti-FRMPD2 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41360R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse,Rat(predicted:Human,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41360R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse,Rat(predicted:Human,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱FRMPD2
    中文名稱FRMPD2抗體
    別    名FERM and PDZ domain containing protein 2; PDZ domain containing protein 4; PDZ domain containing protein 5C; PDZ domain containing 4 PDZD5C; PDZK4; PDZK5C;FRPD2_HUMAN.  
    研究領域腫瘤  細胞生物  免疫學  信號轉導  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Pig, Cow, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量144kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PDZK4:1001-1100/1309 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]

    Function:
    May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).

    Subunit:
    Interacts (via the PDZ 2 domain) with CTNND2 (via the extreme C-terminus). Interacts (via the PDZ 2 domain) with PKP4 (via the extreme C-terminus); this interaction directed FRMPD2 to the basolateral membranes. Interacts (via the PDZ 2 domain) with ARVCF (via the extreme C-terminus).

    Subcellular Location:
    Cytoplasm (Potential). Basolateral cell membrane. Cell junction, tight junction. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.

    Tissue Specificity:
    Expressed in epithelial cells.

    Similarity:
    Contains 1 FERM domain.
    Contains 1 KIND domain.
    Contains 3 PDZ (DHR) domains.

    SWISS:
    Q68DX3

    Gene ID:
    143162

    Database links:

    Entrez Gene: 143162 Human

    SwissProt: Q68DX3 Human

    Unigene: 664786 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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