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    電壓門控鉀通道蛋白1抗體
    • 產品貨號:
      BN41346R
    • 中文名稱:
      電壓門控鉀通道蛋白1抗體
    • 英文名稱:
      Rabbit anti-KCNAB1/Kv beta 1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41346R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,ELISA

    • BN41346R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,ELISA

    產品描述

    英文名稱KCNAB1/Kv beta 1
    中文名稱電壓門控鉀通道蛋白1抗體
    別    名hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; KV-BETA-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1.  
    研究領域細胞生物  神經生物學  通道蛋白  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量47kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1:131-230/419 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming ? subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming ? subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.

    Function:
    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

    Subunit:
    Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity).

    Subcellular Location:
    Cytoplasm.

    Tissue Specificity:
    In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.

    Similarity:
    Belongs to the shaker potassium channel beta subunit family.

    SWISS:
    Q14722

    Gene ID:
    7881

    Database links:

    Entrez Gene: 395730 Chicken

    Entrez Gene: 526133 Cow

    Entrez Gene: 7881 Human

    Entrez Gene: 16497 Mouse

    Entrez Gene: 100125830 Pig

    Entrez Gene: 29737 Rat

    GenBank: NP_751891 Human

    Omim: 601141 Human

    SwissProt: Q9PWR1 Chicken

    SwissProt: Q4PJK1 Cow

    SwissProt: Q14722 Human

    SwissProt: P63143 Mouse

    SwissProt: P63144 Rat

    Unigene: 654519 Human

    Unigene: 703187 Human

    Unigene: 316402 Mouse

    Unigene: 32090 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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