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    首頁>>免疫學>>一抗>>波形蛋白抗體
    波形蛋白抗體
    • 產品貨號:
      BN41335R
    • 中文名稱:
      波形蛋白抗體
    • 英文名稱:
      Rabbit anti-Vimentin Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41335R-100ul

      100ul

      ¥2360.00

      交叉反應:Rabbit,Mouse,Human(predicted:Horse,Cow,Pig,Dog,Rat) 推薦應用:WB,IHC-F,ICC,IF,Flow-Cyt,ELISA

    • BN41335R-200ul

      200ul

      ¥3490.00

      交叉反應:Rabbit,Mouse,Human(predicted:Horse,Cow,Pig,Dog,Rat) 推薦應用:WB,IHC-F,ICC,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱Vimentin
    中文名稱波形蛋白抗體
    別    名VIM; FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin. 
    研究領域腫瘤  細胞生物  免疫學  信號轉導  干細胞  細胞骨架  腫瘤細胞生物標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rabbit,  (predicted: Rat, Dog, Pig, Cow, Horse, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量51kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Vimentin:371-466/466 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

    Function:
    Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Subunit : Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity).

    Subcellular Location:
    Cytoplasm.

    Tissue Specificity:
    Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.

    Post-translational modifications:
    Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin. One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.

    Similarity:
    Belongs to the intermediate filament family.

    SWISS:
    P08670

    Gene ID:
    7431

    Database links:

    Entrez Gene: 7431 Human

    Entrez Gene: 22352 Mouse

    Entrez Gene: 81818 Rat

    Omim: 193060 Human

    SwissProt: P08670 Human

    SwissProt: P20152 Mouse

    SwissProt: P31000 Rat

    Unigene: 455493 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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