最近搜索:細胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁>>免疫學(xué)>>一抗>>X射線修復(fù)交叉互補蛋白4抗體
    X射線修復(fù)交叉互補蛋白4抗體
    • 產(chǎn)品貨號:
      BN41334R
    • 中文名稱:
      X射線修復(fù)交叉互補蛋白4抗體
    • 英文名稱:
      Rabbit anti-XRCC4 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41334R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用:WB,ELISA

    • BN41334R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用:WB,ELISA

    產(chǎn)品描述

    英文名稱XRCC4
    中文名稱X射線修復(fù)交叉互補蛋白4抗體
    別    名DNA double strand break repair and V(D)J recombination protein XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4; DNA repair protein XRCC4; DNA-repair protein XRCC4; X ray repair complementing defective repair in Chinese hamster cells 4 ; X ray repair cross complementing protein 4; X-ray repair complementing defective repair in Chinese hamster cells 4 ; X-ray repair cross-complementing protein 4; XRCC 4; XRCC-4; XRCC4_HUMAN.  
    研究領(lǐng)域細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量38/60kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human XRCC4:151-260/336 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

    Function:
    Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

    Subunit:
    Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Widely expressed.

    Post-translational modifications:
    Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX.
    Monoubiquitinated.
    Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination.

    Similarity:
    Belongs to the XRCC4 family.

    SWISS:
    Q13426

    Gene ID:
    7518

    Database links:

    Entrez Gene: 7518 Human

    Omim: 194363 Human

    SwissProt: Q13426 Human

    Unigene: 567359 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
























    国产亚洲人成网站在线观看| 国产亚洲成归v人片在线观看| 亚洲欧洲日产国码无码久久99| 国产成人 亚洲欧洲| 亚洲精品无码人妻无码| 亚洲sss综合天堂久久久| 亚洲人成人77777在线播放| 亚洲图片激情小说| 精品亚洲国产成人| 亚洲熟妇成人精品一区| 亚洲欧美国产国产一区二区三区| 亚洲日韩一区二区一无码| 亚洲国产精品无码久久98| 亚洲精品无码你懂的| 亚洲aⅴ无码专区在线观看春色 | 亚洲老熟女五十路老熟女bbw| 亚洲一区二区三区在线观看网站 | 亚洲精品午夜无码电影网| 久久精品国产亚洲麻豆| 久久精品亚洲中文字幕无码网站| 亚洲AV永久青草无码精品| 亚洲一区二区电影| 亚洲视频免费在线播放| 亚洲AV无码专区在线亚| 亚洲欧美日韩中文高清www777| 亚洲爆乳无码专区www| 免费观看亚洲人成网站| 中文字幕第一页亚洲| 亚洲精品无码久久久久sm| 亚洲AV成人片色在线观看高潮| 在线观看亚洲人成网站| 亚洲无砖砖区免费| 最新国产精品亚洲| 日韩精品亚洲专区在线观看| 国产成人高清亚洲| 亚洲电影中文字幕| 亚洲不卡中文字幕| 亚洲avav天堂av在线网毛片| 精品国产亚洲男女在线线电影 | 亚洲国产精品嫩草影院| 亚洲精品国产自在久久|