最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>F-box蛋白家族FBXO25抗體
    F-box蛋白家族FBXO25抗體
    • 產(chǎn)品貨號(hào):
      BN41330R
    • 中文名稱:
      F-box蛋白家族FBXO25抗體
    • 英文名稱:
      Rabbit anti-FBXO25 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN41330R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應(yīng)用:WB,ELISA

    • BN41330R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應(yīng)用:WB,ELISA

    產(chǎn)品描述

    英文名稱FBXO25
    中文名稱F-box蛋白家族FBXO25抗體
    別    名F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399;   
    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Mouse, Rat,  (predicted: Human, Pig, Rabbit, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量43kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human FBXO25:55-150/367 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing.
    FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation.

    Function:
    Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity).

    Subunit:
    Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus).

    Subcellular Location:
    Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1

    Tissue Specificity:
    Expressed in all brain tissue observed.

    DISEASE:
    Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4.

    Similarity:
    Contains 1 F-box domain.

    SWISS:
    Q8TCJ0

    Gene ID:
    26260

    Database links:

    Entrez Gene: 26260 Human

    Entrez Gene: 66822 Mouse

    Entrez Gene: 364637 Rat

    Omim: 609098 Human

    SwissProt: Q1RMS8 Cow

    SwissProt: Q8TCJ0 Human

    SwissProt: Q9D2Y6 Mouse

    SwissProt: Q641X7 Rat

    Unigene: 438454 Human

    Unigene: 37950 Mouse

    Unigene: 3663 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.





















    image.png

    image.png


    亚洲一区二区视频在线观看 | 亚洲免费综合色在线视频| 日韩亚洲欧洲在线com91tv| 亚洲日韩中文在线精品第一| 亚洲乱码日产精品一二三| 亚洲免费在线视频观看| 老汉色老汉首页a亚洲| 国产亚洲美女精品久久久久狼| 亚洲综合另类小说色区| 亚洲精品国产精品乱码不卡| 国产亚洲精品欧洲在线观看| www.亚洲色图.com| 亚洲精品无码专区2| 亚洲午夜无码AV毛片久久| 精品国产日韩亚洲一区| 国产亚洲成归v人片在线观看| 国产亚洲自拍一区| 亚洲精品国产品国语在线| 亚洲乱亚洲乱妇无码麻豆| 国产av无码专区亚洲av桃花庵| 国产AV无码专区亚洲AVJULIA| 国产亚洲一区二区精品| 久久久久亚洲精品美女| 亚洲国产精品一区| 91亚洲一区二区在线观看不卡| 亚洲成AV人综合在线观看| 亚洲不卡中文字幕| 亚洲综合精品成人| 日韩色视频一区二区三区亚洲| 亚洲国产主播精品极品网红| 国产亚洲精品高清在线| 国产精一品亚洲二区在线播放| 亚洲Av无码专区国产乱码DVD| 亚洲国产精品一区| 亚洲av午夜电影在线观看| 在线观看亚洲AV每日更新无码| 亚洲国产欧洲综合997久久| 小说区亚洲自拍另类| va亚洲va日韩不卡在线观看| 在线观看国产区亚洲一区成人| 亚洲情XO亚洲色XO无码|