最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁>>免疫學(xué)>>一抗>>RNA結(jié)合蛋白LIN28抗體
    RNA結(jié)合蛋白LIN28抗體
    • 產(chǎn)品貨號:
      BN41327R
    • 中文名稱:
      RNA結(jié)合蛋白LIN28抗體
    • 英文名稱:
      Rabbit anti-Lin28 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41327R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41327R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

    產(chǎn)品描述

    英文名稱Lin28
    中文名稱RNA結(jié)合蛋白LIN28抗體
    別    名Lin 28; Lin28A; Lin 28 homolog (C. elegans); Lin 28 homolog A; Lin 28 homolog; Lin-28;y Lin-28 homolog (C. elegans); Lin-28 homolog A; Lin-28A; Lin28; Lin28a; LN28A_HUMAN; Protein lin-28 homolog A; RNA binding protein lin 28; RNA binding protein lin-28; Tex17; ZCCHC1; Zinc finger CCHC domain containing 1; Zinc finger CCHC domain containing protein 1; Zinc finger CCHC domain-containing protein 1; AL024421; CSDD1.  
    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  表觀遺傳學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量29kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Lin28:75-180/209 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.

    Function:
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

    Subunit:
    Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.

    Subcellular Location:
    Cytoplasm. Nucleus > nucleolus. Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.

    Tissue Specificity:
    Expressed in embryonic stem cells (ES cells), placenta and testis.

    Similarity:
    Belongs to the lin-28 family.
    Contains 2 CCHC-type zinc fingers.
    Contains 1 CSD (cold-shock) domain.

    SWISS:
    Q9H9Z2

    Gene ID:
    79727

    Database links:

    Entrez Gene: 79727 Human

    Entrez Gene: 83557 Mouse

    Entrez Gene: 500562 Rat

    Omim: 611043 Human

    SwissProt: Q9H9Z2 Human

    SwissProt: Q8K3Y3 Mouse

    Unigene: 86154 Human

    Unigene: 302567 Mouse

    Unigene: 147538 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.




















    image.png

    image.png

    image.png

    image.png

    亚洲无码视频在线| 亚洲av成人一区二区三区观看在线| 日本亚洲国产一区二区三区| 中文字幕亚洲色图| 久久久久久亚洲精品无码| 中文字幕亚洲精品| 夜夜亚洲天天久久| 亚洲综合最新无码专区| 亚洲成人一区二区| 亚洲天堂一区二区三区四区| 国产亚洲精品久久久久秋霞| 国产亚洲美女精品久久久| 久久久久一级精品亚洲国产成人综合AV区| 91大神亚洲影视在线| 91精品国产亚洲爽啪在线影院| 亚洲欧洲在线观看| 亚洲一区二区三区影院| 亚洲熟妇无码一区二区三区导航| 亚洲AV无码一区二区二三区软件| 无码专区一va亚洲v专区在线| 亚洲一级视频在线观看| 久久亚洲精品视频| 亚洲国模精品一区| 亚洲欧美日韩一区二区三区| 亚洲校园春色小说| 亚洲va精品中文字幕| 亚洲熟妇久久精品| 亚洲AV无码专区在线电影成人 | 亚洲日本VA中文字幕久久道具| 亚洲欧美日韩一区二区三区在线| 亚洲AV女人18毛片水真多| 亚洲AV无码不卡在线观看下载| 亚洲一区二区视频在线观看| 国产亚洲成av人片在线观看| 4338×亚洲全国最大色成网站| 亚洲欧洲成人精品香蕉网| 亚洲国产国产综合一区首页| 亚洲成AV人片久久| 亚洲另类无码专区首页| 亚洲国产婷婷综合在线精品| 亚洲色WWW成人永久网址|