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    首頁>>免疫學>>一抗>>LRRC41蛋白抗體
    LRRC41蛋白抗體
    • 產品貨號:
      BN41319R
    • 中文名稱:
      LRRC41蛋白抗體
    • 英文名稱:
      Rabbit anti-LRRC41 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41319R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41319R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱LRRC41
    中文名稱LRRC41蛋白抗體
    別    名elongin BC interacting leucine rich repeat protein; Leucine rich repeat containing 41; Leucine rich repeat containing protein 41; MUF1; PP7759; LRC41_HUMAN.  
    研究領域細胞生物  免疫學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量89kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human LRRC41:331-430/812 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

    Function:
    Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

    Subunit:
    Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Contains 7 LRR (leucine-rich) repeats.

    SWISS:
    Q15345

    Gene ID:
    10489

    Database links:

    Entrez Gene: 10489 Human

    Entrez Gene: 230654 Mouse

    Entrez Gene: 362566 Rat

    SwissProt: Q15345 Human

    SwissProt: Q8K1C9 Mouse

    SwissProt: Q5M9H1 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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