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磷酸化三磷酸腺苷依賴解旋酶ddx5抗體

產品貨號：

BN41295R
中文名稱：

磷酸化三磷酸腺苷依賴解旋酶ddx5抗體
英文名稱：

Rabbit anti-phospho-DDX5 (Tyr593) Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41295R-100ul

100ul

￥2470.00

交叉反應：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	phospho-DDX5 (Tyr593)
中文名稱	磷酸化三磷酸腺苷依賴解旋酶ddx5抗體
別名	DDX5 (phospho Y593); DDX5 (phospho Tyr593); p-DDX5 (Y593); p-DDX5 (Tyr593); ATP dependent RNA helicase DDX5; DDX 5; Ddx5; DDX5_HUMAN; DEAD (Asp Glu Ala Asp) box helicase 5; DEAD (Asp Glu Ala Asp) box polypeptide 5; DEAD box 5; DEAD box protein 5; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD); DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase 68kDa); DEAD/H box-5 (RNA helicase 68kD); DKFZp686J01190; G17P1; HELR; HLR 1; HLR1; HUMP68; P68; P68; p68 RNA helicase; Probable ATP dependent RNA helicase DDX5; Probable ATP-dependent RNA helicase DDX5; RNA helicase 68kD; RNA helicase p68; RNA-dependent ATPase.
產品類型	磷酸化抗體
研究領域	發育生物學神經生物學信號轉導激酶和磷酸酶細胞分化表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Rat, (predicted: Mouse, Cow, Horse, Rabbit, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	69kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human DDX5 around the phosphorylation site of Tyr593:QA(p-Y)AY
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	p68 RNA helicase is a nuclear protein that exhibits RNA-dependent ATPase activity. Phosphorylation by protein kinase C inhibits p68 RNA helicase activity. p68 RNA helicase appears to play a role in organ differentiation during development. Furthermore, p68 RNA helicase is expressed in early neural development and in various mesodermal tissues in a number of different chordate embryos. At the cellular level, the expression levels of p68 RNA helicase increases in serum-induced quiescent cell lines. p68 RNA helicase may function as a coactivator for estrogen receptor alpha. Additionally, p68 RNA helicase associates with transcriptional coactivators CBP and p300. p68 RNA helicase localizes to the nucleus under normal conditions. During late telophase, p68 RNA helicase and fibrillarin colocalize to nascent nucleoli. p68 RNA helicase may function as a heterodimer with p72 RNA helicase. Function: RNA-dependent ATPase activity. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. May be involved in pre-mRNA splicing. Subunit: Interacts with BRDT (By similarity). Identified in thespliceosome C complex. Interacts with RBM4; the interaction occursin a RNA-independent manner. Interacts with EIF2C1 and EIF2C2.Interacts with ESR1; the interaction is enhanced by phosphorylationof ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300,CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interactswith DDX17. [INTERACTION] Q12873:CHD3; NbExp=4; IntAct=EBI-351962, EBI-523590;P45481:Crebbp (xeno); NbExp=3; IntAct=EBI-351962, EBI-296306;Q09472:EP300; NbExp=4; IntAct=EBI-351962, EBI-447295; P03372:ESR1;NbExp=8; IntAct=EBI-351962, EBI-78473; P22087:FBL; NbExp=6;IntAct=EBI-351962, EBI-358318; Q13547:HDAC1; NbExp=4;IntAct=EBI-351962, EBI-301834; O95983:MBD3; NbExp=4;IntAct=EBI-351962, EBI-1783068; P10085:Myod1 (xeno); NbExp=3;IntAct=EBI-351962, EBI-4405734; P24928:POLR2A; NbExp=3;IntAct=EBI-351962, EBI-295301; Q08775-3:Runx2 (xeno); NbExp=2;IntAct=EBI-351962, EBI-6119991; P04637:TP53; NbExp=3;IntAct=EBI-351962, EBI-366083; P04637-1:TP53; NbExp=2;IntAct=EBI-351962, EBI-3895849; P04637-7:TP53; NbExp=2;IntAct=EBI-351962, EBI-3895873. Subcellular Location: Nucleus. Post-translational modifications: Arg-502 is dimethylated, probably to asymmetricdimethylarginine. Sumoylated; sumoylation, promoted by PIAS1, promotesinteraction with HDAC1 and transcriptional repression activity.Sumoylation also significantly increases stability, and reducespolyubiquitination. Polyubiquitinated, leading to proteasomal degradation. Similarity: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. SWISS: P17844 Gene ID: 1655 Database links: Entrez Gene: 1655 Human Entrez Gene: 13207 Mouse Entrez Gene: 287765 Rat Omim: 180630 Human SwissProt: P17844 Human SwissProt: Q61656 Mouse Unigene: 279806 Human Unigene: 220038 Mouse Unigene: 162208 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.