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    首頁>>免疫學>>一抗>>冷誘導RNA結合蛋白抗體
    冷誘導RNA結合蛋白抗體
    • 產品貨號:
      BN41275R
    • 中文名稱:
      冷誘導RNA結合蛋白抗體
    • 英文名稱:
      Rabbit anti-CIRBP Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41275R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41275R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱CIRBP
    中文名稱冷誘導RNA結合蛋白抗體
    別    名A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP.  
    研究領域細胞生物  免疫學  細胞周期蛋白  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量19kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human CIRBP:61-172/172 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

    Function:
    Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

    Subunit:
    Interacts with EIF4G1. Associates with ribosomes.

    Subcellular Location:
    Nucleus, nucleoplasm. Cytoplasm.

    Tissue Specificity:
    Ubiquitous.

    Post-translational modifications:
    Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
    Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.

    Similarity:
    Contains 1 RRM (RNA recognition motif) domain.

    SWISS:
    Q14011

    Gene ID:
    1153

    Database links:

    Entrez Gene: 1153 Human

    Omim: 602649 Human

    SwissProt: Q14011 Human

    Unigene: 618145 Human

    Unigene: 634522 Human




    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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