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    激肽原1重鏈抗體
    • 產品貨號:
      BN41262R
    • 中文名稱:
      激肽原1重鏈抗體
    • 英文名稱:
      Rabbit anti-Kininogen 1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41262R-100ul

      100ul

      ¥2360.00

      交叉反應:Human 推薦應用:IHC-P,IHC-F,IF,ELISA

    • BN41262R-200ul

      200ul

      ¥3490.00

      交叉反應:Human 推薦應用:IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱Kininogen 1
    中文名稱激肽原1重鏈抗體
    別    名HMW Kininogen Heavy Chain; HMW Kininogen; Kininogen-1 heavy chain; BDK; Kininogen 1; Kininogen1; Kininogen-1; KNG1; LMW; Low molecular weight growth promoting factor; Low molecular weight kininogen; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; HMWK heavy chain; Ile-Ser-Bradykinin; Kallidin I; Kallidin II; Kininogen 1; Kininogen 1 heavy chain; KNG; KNG1_HUMAN; Williams-Fitzgerald-Flaujeac factor.  
    研究領域心血管  細胞生物  信號轉導  生長因子和激素  細胞骨架  細胞外基質  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, 
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量40/70kDa
    細胞定位細胞外基質 分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Kininogen-1 heavy chain:281-356/644 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

    Function:
    Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

    Subcellular Location:
    Secreted, extracellular space.

    Tissue Specificity:
    Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

    Post-translational modifications:
    Bradykinin is released from kininogen by plasma kallikrein.
    Hydroxylation of Pro-383 occurs prior to the release of bradykinin.
    Phosphorylation sites are present in the extracellular medium.
    N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

    Similarity:
    Contains 3 cystatin kininogen-type domains.

    SWISS:
    P01042

    Gene ID:
    3827

    Database links:

    Entrez Gene: 3827 Human

    Omim: 228960 Human

    SwissProt: P01042 Human

    Unigene: 77741 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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