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    磷脂酰肌醇激酶催化亞單位p101抗體
    • 產品貨號:
      BN41251R
    • 中文名稱:
      磷脂酰肌醇激酶催化亞單位p101抗體
    • 英文名稱:
      Rabbit anti-PIK3R5 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41251R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse(predicted:Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    • BN41251R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse(predicted:Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱PIK3R5
    中文名稱磷脂酰肌醇激酶催化亞單位p101抗體
    別    名PIK3R5; PIK3 R5; PI 3-kinase p101; PI3K p101; PI3R5_HUMAN; Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K; p101-PI3K; FOAP 2; FOAP2.  
    研究領域腫瘤  細胞生物  信號轉導  細胞周期蛋白  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量97kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PIK3R5:701-800/880 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

    Function:
    Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.

    Subunit:
    Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.

    Subcellular Location:
    Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.

    Tissue Specificity:
    Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.

    DISEASE:
    Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. Note=The disease is caused by mutations affecting the gene represented in this entry.

    SWISS:
    Q8WYR1

    Gene ID:
    23533

    Database links:

    Entrez Gene: 23533 Human

    Entrez Gene: 320207 Mouse

    Entrez Gene: 497931 Rat

    Omim: 611317 Human

    SwissProt: Q8WYR1 Human

    SwissProt: Q5SW28 Mouse

    Unigene: 278901 Human

    Unigene: 738684 Human

    Unigene: 244960 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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