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    首頁>>免疫學(xué)>>一抗>>腦特定蛋白Brn3B抗體
    腦特定蛋白Brn3B抗體
    • 產(chǎn)品貨號:
      BN41240R
    • 中文名稱:
      腦特定蛋白Brn3B抗體
    • 英文名稱:
      Rabbit anti-BRN3B Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41240R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41240R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱BRN3B
    中文名稱腦特定蛋白Brn3B抗體
    別    名BRN3B; class 4; transcription factor 2; Brain specific homeobox/POU domain protein 3B; Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3B; BRN3.2; Brn3b POU domain transcription factor; PO4F2_HUMAN; POU class 4 homeobox 2; POU domain; POU domain class 4 transcription factor 2; POU domain protein; POU4F2.  
    研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  表觀遺傳學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /Test IF=1:50-200 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量41kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human BRN3B/POU4F2:301-400/409 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU (Pit-Oct-Unc) domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus and one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development and differentiation.

    Function:
    Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

    Subcellular Location:
    Nucleus speckle.

    Tissue Specificity:
    Brain. Seems to be specific to the retina.

    Similarity:
    Belongs to the POU transcription factor family. Class-4 subfamily.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 POU-specific domain.

    SWISS:
    Q12837

    Gene ID:
    5458

    Database links:
    UniProtKB/Swiss-Prot: Q12837.2

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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