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    17-β-羥脫氫酶6抗體
    • 產品貨號:
      BN41222R
    • 中文名稱:
      17-β-羥脫氫酶6抗體
    • 英文名稱:
      Rabbit anti-HSD17B6 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41222R-100ul

      100ul

      ¥2360.00

      交叉反應:Human(predicted:Mouse,Rat,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41222R-200ul

      200ul

      ¥3490.00

      交叉反應:Human(predicted:Mouse,Rat,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱HSD17B6
    中文名稱17-β-羥脫氫酶6抗體
    別    名17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3 hydroxysteroid epimerase; 3(alpha >beta) hydroxysteroid epimerase; 3(alpha >beta) hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; H17B6_HUMAN; HSD17B6; HSE; Hydroxysteroid (17 beta) dehydrogenase 6; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse); Hydroxysteroid 17 beta dehydrogenase 6; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase; Oxidative 3 alpha hydroxysteroid dehydrogenase; Oxidative 3-alpha hydroxysteroid dehydrogenase; Oxidoreductase; Retinol dehydrogenase; RODH; SDR9C6;Short chain dehydrogenase/reductase family 9C, member 6.  
    研究領域信號轉導  生長因子和激素  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Pig, Horse, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量33kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human HSD17B6:61-160/317 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

    Function:
    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

    Subcellular Location:
    Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side (Potential).

    Tissue Specificity:
    Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.

    Similarity:
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.

    SWISS:
    O14756

    Gene ID:
    8630

    Database links:

    Entrez Gene: 8630 Human

    Entrez Gene: 27400 Mouse

    Entrez Gene: 286964 Rat

    Omim: 606623 Human

    SwissProt: Q3T001 Cow

    SwissProt: O14756 Human

    SwissProt: Q9R092 Mouse

    SwissProt: O54753 Rat

    Unigene: 524513 Human

    Unigene: 26719 Mouse

    Unigene: 10857 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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