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    甲狀腺激素受體α1+α2抗體
    • 產品貨號:
      BN41202R
    • 中文名稱:
      甲狀腺激素受體α1+α2抗體
    • 英文名稱:
      Rabbit anti-THRA1+2 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41202R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Zebrafish,Sheep,Cat) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    • BN41202R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Zebrafish,Sheep,Cat) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱THRA1+2
    中文名稱甲狀腺激素受體α1+α2抗體
    別    名Thyroid Hormone Receptor alpha 1+2; THRA1+THRA2; AR7; Avian erythroblastic leukemia viral (v erb a) oncogene homolog; c ERBA 1; c ERBA ALPHA 2; C erbA alpha; c-erbA-1; C-erbA-alpha; cerbA protein; cerbAalpha; EAR 7; EAR 7.1; EAR 7.2; EAR-7; EAR7; ERB T 1; ERBA 1; ERBA ALPHA; ERBA; ERBA related 7; ERBA1; Erythroblastic leukemia viral (v erb a) oncogene homolog avian; NR1A 1; Nr1a1; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (verba) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7. 






    研究領域腫瘤  細胞生物  染色質和核信號  神經生物學  信號轉導  轉錄調節因子  內分泌病  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Zebrafish, Sheep, Cat, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量55kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human THRA1 and THRA2:101-200/490 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

    Function:
    Nuclear hormone receptor. High affinity receptor for triiodothyronine.

    Subunit:
    Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.

    Subcellular Location:
    Nucleus.

    DISEASE:
    Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.

    Similarity:
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.

    SWISS:
    P10827

    Gene ID:
    7067

    Database links:

    Entrez Gene: 7067 Human

    Entrez Gene: 21833 Mouse

    Entrez Gene: 81812 Rat

    Omim: 190120 Human

    SwissProt: P10827 Human

    SwissProt: P63058 Mouse

    SwissProt: O97716 Pig

    SwissProt: P63059 Rat

    Unigene: 724 Human

    Unigene: 265917 Mouse

    Unigene: 442648 Mouse

    Unigene: 11307 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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