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    磷酸化1型神經纖維瘤抗體
    • 產品貨號:
      BN41135R
    • 中文名稱:
      磷酸化1型神經纖維瘤抗體
    • 英文名稱:
      Rabbit anti-phospho-NF1 (Ser2515) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

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    • BN41135R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Mouse(predicted:Rat,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱phospho-NF1 (Ser2515)
    中文名稱磷酸化1型神經纖維瘤抗體
    別    名NF1(phospho S2515); NF1(phospho Ser2515); p-NF1(S2515); DKFZp686J1293; FLJ21220; Neurofibromatosis Noonan syndrome; Neurofibromatosis related protein NF 1; Neurofibromatosis related protein NF1; neurofibromatosis type I; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Neurofibromin1; NF 1; NF; NF1; NF1_HUMAN; NFNS; Type 1 Neurofibromatosis; von Recklinghausen disease neurofibromin; von Recklinghausen disease related protein VRNF; VRNF; WATS; Watson disease related protein WSS; Watson syndrome; WSS.  
    產品類型磷酸化抗體 
    研究領域腫瘤  細胞生物  免疫學  染色質和核信號  神經生物學  信號轉導  表觀遺傳學  G蛋白信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量147/319kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human NF1 around the phosphorylation site of Ser2515:QT(p-S)PR 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.

    Function:
    Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

    DISEASE:
    Neurofibromatosis 1 (NF1) [MIM:162200]: A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris, tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Watson syndrome (WS) [MIM:193520]: A syndrome characterized by the presence of pulmonary stenosis, cafe-au-lait spots, and mental retardation. It is considered as an atypical form of neurofibromatosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Familial spinal neurofibromatosis (FSNF) [MIM:162210]: Considered to be an alternative form of neurofibromatosis, showing multiple spinal tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Neurofibromatosis-Noonan syndrome (NFNS) [MIM:601321]: Characterized by manifestations of both NF1 and Noonan syndrome (NS). NS is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.

    Similarity:
    Contains 1 CRAL-TRIO domain.
    Contains 1 Ras-GAP domain.

    SWISS:
    P21359

    Gene ID:
    4763

    Database links:

    Entrez Gene: 4763 Human

    Entrez Gene: 18015 Mouse

    Entrez Gene: 24592 Rat

    Omim: 613113 Human

    SwissProt: P21359 Human

    SwissProt: Q04690 Mouse

    SwissProt: P97526 Rat

    Unigene: 113577 Human

    Unigene: 255596 Mouse

    Unigene: 10686 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application























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