最近搜索:細胞培養(yǎng) 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>磷酸化細胞核因子p50/k基因結(jié)合核因子抗體
    磷酸化細胞核因子p50/k基因結(jié)合核因子抗體
    • 產(chǎn)品貨號:
      BN41115R
    • 中文名稱:
      磷酸化細胞核因子p50/k基因結(jié)合核因子抗體
    • 英文名稱:
      Rabbit anti-Phospho-NFKB1 (Thr931) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN41115R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱Phospho-NFKB1 (Thr931)
    中文名稱磷酸化細胞核因子p50/k基因結(jié)合核因子抗體
    別    名NFKB1(phospho T931); NFKB1(phospho Thr931); NF kappa B; NFKB 1; NFKB p105; NFKB p50; NFKB1; Nuclear factor kappa B DNA binding subunit; Nuclear factor NF kappa B p105 subunit; Nuclear factor NF kappa B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 1; DKFZp686C01211; DNA binding factor KBF1; DNA binding factor KBF1 EBP1; EBP 1; EBP1; KBF1; MGC54151; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nfkb1; NF-kappaB; NF-kappaB1; NF-KB1; p105; p50; p50/p105; DKFZp686C01211; EBP-1; KBF1; MGC54151; Nf kappa b DNA binding subunit; NF-KAPPAB; NF-KAPPAB1; NFKB; NFKB SUBUNIT P105/P50; NFKB-p105; NFKB1; NUCLEAR FACTOR KAPPA B DNA BINDING SUBUNIT; p105 Nfkb;p50 NF-kappa B;p50NFKB.  
    產(chǎn)品類型磷酸化抗體 
    研究領(lǐng)域腫瘤  免疫學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, )
    產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量105kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human NF KappaB p105 around the phosphorylation site of Thr931:VE(p-T)SF 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. SUBUNIT: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL.

    Function:
    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

    Subunit:
    Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID. Directly interacts with MEN1. Interacts with HIF1AN.

    Subcellular Location:
    Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

    Post-translational modifications:
    While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
    Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.
    Polyubiquitination seems to allow p105 processing.
    S-nitrosylation of Cys-61 affects DNA binding.
    The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.

    Similarity:
    Contains 7 ANK repeats.
    Contains 1 death domain.
    Contains 1 RHD (Rel-like) domain.

    SWISS:
    P19838

    Gene ID:
    4790

    Database links:

    Entrez Gene: 4790 Human

    Entrez Gene: 18033 Mouse

    Entrez Gene: 81736 Rat

    Omim: 164011 Human

    SwissProt: P19838 Human

    SwissProt: P25799 Mouse

    SwissProt: Q63369 Rat

    Unigene: 618430 Human

    Unigene: 256765 Mouse

    Unigene: 2411 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


    国产亚洲AV手机在线观看 | 亚洲理论精品午夜电影| 国精无码欧精品亚洲一区 | 亚洲 综合 国产 欧洲 丝袜| 日韩欧美亚洲中文乱码| 亚洲av无码偷拍在线观看| 亚洲另类无码专区首页| 亚洲国产成人无码AV在线影院| 亚洲色成人网站WWW永久四虎| 亚洲熟妇AV日韩熟妇在线| 亚洲日韩中文字幕一区| 亚洲heyzo专区无码综合| 亚洲AV无码AV日韩AV网站| 亚洲.国产.欧美一区二区三区| 亚洲AV女人18毛片水真多| 成人伊人亚洲人综合网站222| 日韩精品成人亚洲专区| 亚洲国产综合人成综合网站| 国产精品亚洲αv天堂无码| 国产aⅴ无码专区亚洲av麻豆| 亚洲精品成人无限看| 亚洲另类激情综合偷自拍| 亚洲精品视频专区| 国产精品高清视亚洲精品| 香蕉大伊亚洲人在线观看| 亚洲成av人片在线天堂无| 一本久到久久亚洲综合| 亚洲最大av无码网址| 久久精品国产亚洲网站| 久久亚洲日韩精品一区二区三区| 久久综合亚洲色HEZYO社区| 亚洲13又紧又嫩又水多| 亚洲精品无码久久久久APP| 亚洲av日韩片在线观看| 亚洲色精品88色婷婷七月丁香 | 亚洲日韩看片无码电影| 亚洲第一福利网站在线观看| 狠狠亚洲狠狠欧洲2019| 亚洲AV成人一区二区三区AV| 亚洲小说图片视频| 亚洲妇女无套内射精|