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    組蛋白去乙酰化酶1抗體
    • 產品貨號:
      BN41113R
    • 中文名稱:
      組蛋白去乙酰化酶1抗體
    • 英文名稱:
      Rabbit anti-HDAC1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

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    • BN41113R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Rat(predicted:Mouse) 推薦應用:WB,IHC-P,IHC-F,ICC,IF

    產品描述

    英文名稱HDAC1
    中文名稱組蛋白去乙酰化酶1抗體
    別    名HD 1; HD1; HDAC 1; hdac1: histone deacetylase 1; Histone deacetylase 1 (HD1); Histone deacetylase 1; RPD3 (reduced potassium dependency yeast homolog) like 1; RPD3 (reduced potassium dependency); RPD3; RPD3L1; DKFZp686H12203; GON 10; HDAC1_HUMAN.  
    研究領域腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Rat,  (predicted: Mouse, )
    產品應用WB=1:500-2000 IP=1:50-100 IHC-P=1:100-200 IHC-F=1:100-200 ICC=1:100 IF=1:50-100 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量55kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human HDAC1 :393-482/482 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMedPubMed
    產品介紹Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

    Function:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

    Post-translational modifications:
    Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
    Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
    Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.

    Similarity:
    Belongs to the histone deacetylase family. HD type 1 subfamily.

    SWISS:
    Q13547

    Gene ID:
    3065

    Database links:

    Entrez Gene: 404126 Cow

    Entrez Gene: 3065 Human

    Entrez Gene: 433759 Mouse

    Entrez Gene: 297893 Rat

    Omim: 601241 Human

    SwissProt: Q32PJ8 Cow

    SwissProt: Q13547 Human

    SwissProt: O09106 Mouse

    SwissProt: Q4QQW4 Rat

    Unigene: 88556 Human

    Unigene: 202504 Mouse

    Unigene: 391033 Mouse

    Unigene: 1863 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications


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