最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>磷酸化微管相關蛋白抗體
    磷酸化微管相關蛋白抗體
    • 產品貨號:
      BN41102R
    • 中文名稱:
      磷酸化微管相關蛋白抗體
    • 英文名稱:
      Rabbit anti-phospho-Tau (Ser416) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41102R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse) 推薦應用:WB,Flow-Cyt,ELISA

    產品描述

    英文名稱phospho-Tau (Ser416)
    中文名稱磷酸化微管相關蛋白抗體
    別    名Tau (phospho S416); p-Tau (phospho S416); MAPT(phospho S416); MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 subunit interacting factor 1; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau; PHF-tau; PPND; pTau; RNPTAU; Tauopathy and respiratory failure, included; TAU_HUMAN.  
    產品類型磷酸化抗體 
    研究領域免疫學  神經生物學  信號轉導  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量52/79kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human phospho-Tau (Thr181):TG(p-S)ID 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

    Function:
    Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

    Subunit:
    Interacts with PSMC2 through SQSTM1. Interacts with SQSTM1 when polyubiquitinated. Interacts with FKBP4. Binds to CSNK1D. Interacts with SGK1.

    Subcellular Location:
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

    Tissue Specificity:
    Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

    Post-translational modifications:
    Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1: CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Phosphorylation decreases with age. Phosphorylation within tau/MAP's repeat domain or in flanking regions seems to reduce tAU/MAP's interaction with, respectively, microtubules or plasma membrane components. Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Phosphorylation at Ser-548 by GSK3B reduces ability to bind and stabilize microtubules. Phosphorylation at Ser-579 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively. Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717.

    Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome. PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur.

    O-glycosylated. O-GlcNAcylation content is around 8.2%. There is reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively. O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%.

    Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.

    DISEASE:
    Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations.

    Defects in MAPT are a cause of frontotemporal dementia (FTD) [MIM:600274]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.

    Defects in MAPT are a cause of Pick disease of the brain (PIDB) [MIM:172700]. It is a rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration.

    Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.

    Defects in MAPT are a cause of progressive supranuclear palsy type 1 (PSNP1) [MIM:601104]; also abbreviated as PSP and also known as Steele-Richardson-Olszewski syndrome. PSNP1 is characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613.

    Defects in MAPT are a cause of Parkinson-dementia syndrome (PARDE) [MIM:260540]. A syndrome characterized by parkinsonism tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.

    Similarity:
    Contains 4 Tau/MAP repeats.

    SWISS:
    P10636

    Gene ID:
    4137

    Database links:

    Entrez Gene: 281296 Cow

    Entrez Gene: 4137 Human

    Entrez Gene: 17762 Mouse

    Entrez Gene: 29477 Rat

    Omim: 157140 Human

    SwissProt: P29172 Cow

    SwissProt: P10636 Human

    SwissProt: P10637 Mouse

    SwissProt: P19332 Rat

    Unigene: 101174 Human

    Unigene: 1287 Mouse

    Unigene: 2455 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    P-tau蛋白是腦內神經元細胞支架蛋白之一。其正常功能是促進微管蛋白組成微管,并維持已形成微管的穩定性。參與維持細胞形態、信息傳遞、細胞分裂等重要生物學過程,是軸突生長發育和神經元極性形成的不可缺少因素。近年來發現tau蛋白與一些中樞神經系統變性疾病密切相關,尤其是神經Tau具有啟動微管系統的裝配以及穩定微管系統的作用,該蛋白的錯誤折疊與老年性癡呆等神經退行性疾病密切相關。


    亚洲日韩一区二区三区| 亚洲日韩aⅴ在线视频| 亚洲Av无码乱码在线播放| 亚洲依依成人精品| 91天堂素人精品系列全集亚洲| 国产国拍亚洲精品mv在线观看| 亚洲小说区图片区另类春色| 国产精品亚洲高清一区二区| 亚洲一级特黄大片无码毛片| 亚洲精品视频在线看| 亚洲精品国自产拍在线观看| 亚洲精品第一国产综合精品99| 亚洲国产免费综合| 久久精品国产亚洲Aⅴ香蕉 | 亚洲电影唐人社一区二区| 91嫩草私人成人亚洲影院| 亚洲第一网站免费视频| 亚洲国产午夜电影在线入口| 亚洲av永久综合在线观看尤物| 国产成人精品日本亚洲11| 亚洲午夜无码久久| 亚洲gay片在线gv网站| 国产精品亚洲二区在线| 亚洲人成网站色在线入口| 红杏亚洲影院一区二区三区| 亚洲精品无码Av人在线观看国产| 亚洲精品~无码抽插| 久久亚洲成a人片| 亚洲成人黄色网址| 亚洲偷偷自拍高清| 亚洲日韩在线中文字幕综合| 亚洲国产一区二区视频网站| 亚洲性日韩精品一区二区三区 | 亚洲色av性色在线观无码| 日韩亚洲AV无码一区二区不卡| 亚洲国产精品综合福利专区| 成人区精品一区二区不卡亚洲| 亚洲sm另类一区二区三区| 亚洲国产午夜中文字幕精品黄网站| 亚洲一区二区三区影院| 亚洲国产成人片在线观看 |