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    磷酸化原癌基因c-Jun抗體
    • 產品貨號:
      BN41100R
    • 中文名稱:
      磷酸化原癌基因c-Jun抗體
    • 英文名稱:
      Rabbit anti-phospho-c-Jun (Thr91) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41100R-100ul

      100ul

      ¥2470.00

      交叉反應:Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱phospho-c-Jun (Thr91)
    中文名稱磷酸化原癌基因c-Jun抗體
    別    名c-Jun (phospho T91); c-Jun (phospho Thr91); p-c-Jun (Thr91); Transcription factor AP-1; Jun oncogene; JUN; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN protein; JUNC; p39; Proto oncogene cJun; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; JUN_HUMAN; Activator 1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog.  
    產品類型磷酸化抗體 
    研究領域腫瘤  細胞生物  免疫學  信號轉導  轉錄調節因子  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量43kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human c-Jun around the phosphorylation site of Thr91:TT(p-T)PT 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

    Function:
    Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

    Subunit:
    Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.

    Subcellular Location:
    Nucleus.

    Post-translational modifications:
    Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
    Acetylated at Lys-271 by EP300.

    Similarity:
    Belongs to the bZIP family. Jun subfamily.
    Contains 1 bZIP (basic-leucine zipper) domain.

    SWISS:
    P05412

    Gene ID:
    3725

    Database links:

    Entrez Gene: 3725 Human

    Entrez Gene: 16476 Mouse

    Entrez Gene: 396913 Pig

    Entrez Gene: 24516 Rat

    Omim: 165160 Human

    SwissProt: P05412 Human

    SwissProt: P05627 Mouse

    SwissProt: P56432 Pig

    SwissProt: P17325 Rat

    Unigene: 525704 Human

    Unigene: 696684 Human

    Unigene: 275071 Mouse

    Unigene: 93714 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    C-jun(Oncoprotein C-jun:active protein 1)基因與鳥類肉瘤病毒17的轉化基因具有同源性,是早期應答基因家族成員之一。主要用于各種惡性腫瘤的研究。 C-jun又稱:應激活化蛋白激酶。


























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