最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>磷酸化絲裂原活化蛋白激酶激酶5抗體
    磷酸化絲裂原活化蛋白激酶激酶5抗體
    • 產品貨號:
      BN41097R
    • 中文名稱:
      磷酸化絲裂原活化蛋白激酶激酶5抗體
    • 英文名稱:
      Rabbit anti-phospho-MEK5 (Ser129) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41097R-100ul

      100ul

      ¥2470.00

      交叉反應:Human(predicted:Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱phospho-MEK5 (Ser129)
    中文名稱磷酸化絲裂原活化蛋白激酶激酶5抗體
    別    名MAP2K5(phospho S129); Dual specificity mitogen activated protein kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5; EC 2.7.12.2; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAP2K5; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; MEK 5; mitogen-activated protein kinase kinase 5; MKK5; MP2K5_HUMAN; PRKMK5; Protein kinase, mitogen-activated, kinase 5; SAPKK5; SKK5.   
    產品類型磷酸化抗體 
    研究領域腫瘤  免疫學  信號轉導  轉錄調節因子  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量50kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MEK5 around the phosphorylation site of Ser129:GP(p-S)QH 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹MEK5 is a dual specificity protein kinase belonging to thr Ser/Thr protein kinase family, (MAP kinase kinase family). It is activated by phosphorylation on Ser/Thr by MAP kinase kinases and interacts specifically with ERK5, and not with another MAP kinase like P38. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). It is not phosphorylated by RAFA, RAFB or RAFC and it may interact with GTPases such as CDC42. The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. MEK5 is expressed in many adult tissues and is most abundant in heart and skeletal muscle.

    Function:
    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.

    Subunit:
    Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.

    Tissue Specificity:
    Expressed in many adult tissues. Abundant in heart and skeletal muscle.

    Post-translational modifications:
    Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

    Similarity:
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 OPR domain.
    Contains 1 protein kinase domain.

    SWISS:
    Q13163

    Gene ID:
    5607

    Database links:

    Entrez Gene: 5607 Human

    Entrez Gene: 23938 Mouse

    Entrez Gene: 29568 Rat

    Omim: 602520 Human

    SwissProt: Q13163 Human

    SwissProt: Q9WVS7 Mouse

    SwissProt: Q62862 Rat

    Unigene: 114198 Human

    Unigene: 325746 Mouse

    Unigene: 11054 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















    自拍偷自拍亚洲精品被多人伦好爽 | 亚洲午夜精品在线| 国产亚洲精久久久久久无码77777| 国产综合成人亚洲区| 亚洲精品无码专区| 亚洲av永久中文无码精品综合| 亚洲中文字幕一区精品自拍| 亚洲国产视频久久| 亚洲精品无码久久| 亚洲国产精品无码观看久久| 亚洲精品伦理熟女国产一区二区| 亚洲色成人四虎在线观看| 亚洲另类无码专区首页| 亚洲av无码片vr一区二区三区 | 精品亚洲视频在线观看| 国产精品亚洲综合专区片高清久久久| 亚洲AV无码乱码在线观看| www国产亚洲精品久久久| 亚洲国产精品综合久久一线| 亚洲一区二区三区在线播放| 亚洲综合日韩久久成人AV| 亚洲日韩激情无码一区| 亚洲AV午夜福利精品一区二区| 亚洲产国偷V产偷V自拍色戒| 亚洲精品私拍国产福利在线| 亚洲综合色一区二区三区小说| 91亚洲精品自在在线观看| 2020久久精品亚洲热综合一本| 亚洲永久网址在线观看| 亚洲AV无码国产剧情| 亚洲国产综合精品一区在线播放| 毛茸茸bbw亚洲人| 亚洲av无码潮喷在线观看| 久久av无码专区亚洲av桃花岛| 亚洲大尺码专区影院| 亚洲色欲色欱wwW在线| 午夜亚洲国产成人不卡在线| 中文字幕第一页亚洲| 亚洲视频在线免费观看| 激情内射亚洲一区二区三区爱妻| 亚洲日本一线产区和二线|