最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>磷酸化低密度脂蛋白受體相關(guān)蛋白6抗體
    磷酸化低密度脂蛋白受體相關(guān)蛋白6抗體
    • 產(chǎn)品貨號(hào):
      BN41091R
    • 中文名稱:
      磷酸化低密度脂蛋白受體相關(guān)蛋白6抗體
    • 英文名稱:
      Rabbit anti-Phospho-LRP6 (Thr1479) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN41091R-100ul

      100ul

      ¥2470.00

      交叉反應(yīng):Human,Mouse(predicted:Dog,Pig,Cow,Horse,Rabbit,GuineaPig) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱Phospho-LRP6 (Thr1479)
    中文名稱磷酸化低密度脂蛋白受體相關(guān)蛋白6抗體
    別    名LRP6 (Phospho-Thr1479); LRP6 (Phospho-T1479); p-LRP6 (Thr1479); p-LRP6 (T1479); ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6.  
    產(chǎn)品類型磷酸化抗體 
    研究領(lǐng)域腫瘤  心血管  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  合成與降解  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量175kDa
    細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG(p-T)YF <Cytoplasmic>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].

    Function:
    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.

    Subunit:
    Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Forms a WNT-signaling complex formed of a WNT protein, a FZD protein and LRP5 or LRP6. Interacts (via the extracellular domain) with WNT1; the interaction is enhanced by prior formation of the Wnt/Fzd complex. Interacts (via the beta-propeller regions 3 and 4) with WNT3A. Interacts (via the beta-propeller regions 1 and 2) with WNT9B. Interacts with FZD5; the interaction forms a coreceptor complex for Wnt signaling and is inhibited by DKK1 and C1orf187. Interacts (via beta propeller regions 3 and 4) with DKK1; the interaction inhibits FZD5/LRP6 complex formation. Interacts with DKK2. Interacts with C1orf187/DRAXIN; the interaction inhibits Wnt signaling. Interacts (via the phosphorylated PPPSP motifs) with AXIN1; the interaction recruits the AXIN1/GSK3B complex to cell surface LRP6 signalsomes. Interacts with GRB10; the interaction prevents AXIN1 binding, thus negatively regulating the Wnt signaling pathway. Interacts (via the extracellular domain) with RSPO1; the interaction activates Wnt/beta-catenin signaling. Interacts (via the extracellular domain) with RSPO3 (via the cysteine rich domain); the interaction activates Wnt/beta-catenin signaling. Interacts (via the beta-propeller regions 1 and 2) with SOST; the interaction competes with DKK1 for binding for inhibiting beta-catenin signaling. Interacts with MESD; the interaction prevents the formation of LRP6 aggregates and targets LRP6 to the plasma membrane. Interacts (via the cytoplasmic domain) with CSNKIE; the interaction phosphorylates LRP6, binds AXIN1 and inhibits AXIN1/GSK3B-mediated phosphorylation of beta-catenin. Interacts with MACF1.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.

    Tissue Specificity:
    Widely co-expressed with LRP5 during embryogenesis and in adult tissues.

    Post-translational modifications:
    Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3-mediated phosphorylation of beta-catenin. Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs. Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle. Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1. Phosphorylated, in vitro, by casein kinase I on Thr-1479.
    Undergoes gamma-secretase-dependent regulated intramembrane proteolysis (RIP). The extracellular domain is first released by shedding, and then, through the action of gamma-secretase, the intracellular domain (ICD) is released into the cytoplasm where it is free to bind to GSK3B and to activate canonical Wnt signaling.
    Palmitoylation on the two sites near the transmembrane domain leads to release of LRP6 from the endoplasmic reticulum.
    Mono-ubiquitinated which retains LRP6 in the endoplasmic reticulum.
    N-glycosylation is required for cell surface location.

    DISEASE:
    Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947].

    Similarity:
    Belongs to the LDLR family.
    Contains 4 EGF-like domains.
    Contains 3 LDL-receptor class A domains.
    Contains 20 LDL-receptor class B repeats.

    SWISS:
    O75581

    Gene ID:
    4040

    Database links:

    Entrez Gene: 4040 Human

    Entrez Gene: 16974 Mouse

    Omim: 603507 Human

    SwissProt: O75581 Human

    SwissProt: O88572 Mouse

    Unigene: 584775 Human

    Unigene: 658913 Human

    Unigene: 321990 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications


    亚洲一区二区电影| 亚洲国产精品精华液| ass亚洲**毛茸茸pics| 亚洲毛片基地日韩毛片基地| 日本红怡院亚洲红怡院最新 | 久久青青草原亚洲AV无码麻豆| 久久久无码精品亚洲日韩软件| 无码欧精品亚洲日韩一区夜夜嗨 | 亚洲av无码片区一区二区三区| 亚洲制服丝袜精品久久| 亚洲女人初试黑人巨高清| 亚洲福利视频一区二区三区| 亚洲国产综合在线| 亚洲人妖女同在线播放| 亚洲三级高清免费| 在线a亚洲老鸭窝天堂av高清| 中文日韩亚洲欧美制服| 亚洲精品人成网线在线播放va | 中文字幕在亚洲第一在线| 亚洲小说区图片区另类春色| 亚洲人成人网站色www| 久久精品国产亚洲AV果冻传媒| 午夜影视日本亚洲欧洲精品一区| 亚洲午夜精品一区二区| 亚洲精品一卡2卡3卡三卡四卡| 亚洲国产综合第一精品小说| 亚洲毛片基地4455ww| 亚洲美国产亚洲AV| 国产亚洲精品免费| 中文字幕精品无码亚洲字| 亚洲精品无码久久久久去q| 久久久亚洲欧洲日产国码农村| 亚洲黄色网址在线观看| 亚洲一区在线视频观看| 亚洲国产精品自在自线观看| mm1313亚洲精品国产| 亚洲中文字幕无码不卡电影| 久久亚洲免费视频| 亚洲毛片免费视频| 亚洲国产一区二区三区在线观看| 亚洲成AⅤ人影院在线观看|