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    首頁>>免疫學>>一抗>>磷酸化半胱氨酸蛋白酶9抗體
    磷酸化半胱氨酸蛋白酶9抗體
    • 產品貨號:
      BN41064R
    • 中文名稱:
      磷酸化半胱氨酸蛋白酶9抗體
    • 英文名稱:
      Rabbit anti-Phospho-Caspase-9 (Ser196) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN41064R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Mouse,Rat 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱Phospho-Caspase-9 (Ser196)
    中文名稱磷酸化半胱氨酸蛋白酶9抗體
    別    名APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor 3; Apoptotic protease Mch 6; CASP 9; CASP9; Caspase 9 Dominant Negative; Caspase 9 precursor; Caspase 9c; Caspase9; EC 3.4.22.; ICE LAP6; ICE like apoptotic protease 6; MCH6 antibody RNCASP9; CASP9_HUMAN.  
    產品類型磷酸化抗體 
    研究領域腫瘤  免疫學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量35kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CASP9 around the phosphorylation site of Ser196:FS(p-S)LH 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 intereacts with BIRC7 and has been shown to cleave PARP and vimentin.

    Function:
    Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
    Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

    Subunit:
    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7. Interacts (inactive form) with EFHD2. Interacts with HAX1.

    Tissue Specificity:
    Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

    Post-translational modifications:
    Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
    Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation.

    Similarity:
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.

    SWISS:
    P55211

    Gene ID:
    842

    Database links:

    Entrez Gene: 842 Human

    Entrez Gene: 12371 Mouse

    Entrez Gene: 58918 Rat

    Omim: 602234 Human

    SwissProt: P55211 Human

    SwissProt: Q4FJK5 Mouse

    SwissProt: Q920G4 Rat

    Unigene: 329502 Human

    Unigene: 88829 Mouse

    Unigene: 32199 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Caspase-9半胱氨酸蛋白酶家族成員之一,又稱ICE-Lap6(ICE Like apoptotease 6)參與細胞凋亡過程和細胞因子的加工過程,在許多胚胎和成人組織中都有分布。此抗體主要用于腫瘤凋亡的研究。


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