最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
    首頁(yè)>>免疫學(xué)>>一抗>>磷酸化P27抗體/周期素依賴(lài)激酶抑制劑抗體
    磷酸化P27抗體/周期素依賴(lài)激酶抑制劑抗體
    • 產(chǎn)品貨號(hào):
      BN41059R
    • 中文名稱(chēng):
      磷酸化P27抗體/周期素依賴(lài)激酶抑制劑抗體
    • 英文名稱(chēng):
      Rabbit anti-phospho-CDKN1B (Thr157) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN41059R-100ul

      100ul

      ¥2470.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Rabbit,GuineaPig) 推薦應(yīng)用:WB,IHC-P,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)phospho-CDKN1B (Thr157)
    中文名稱(chēng)磷酸化P27抗體/周期素依賴(lài)激酶抑制劑抗體
    別    名p27 KIP 1 (phospho T157); p-p27 KIP 1 (phospho T157); p27Kip1(Phospho-Thr157); p-p27Kip1(Thr157); p-p27Kip1(T157); CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.  
    產(chǎn)品類(lèi)型磷酸化抗體 
    研究領(lǐng)域免疫學(xué)  細(xì)胞周期蛋白  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1μg/Test (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量22kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CDKN1B around the phosphorylation site of Thr157:PA(p-T)DD 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]

    Function:
    Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

    Subunit:
    Forms a ternary compex with CCNE1/CDK2/CDKN1B.

    Subcellular Location:
    Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells.

    Tissue Specificity:
    Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

    Post-translational modifications:
    Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
    Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.

    DISEASE:
    Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) . Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.

    Similarity:
    Belongs to the CDI family.

    SWISS:
    P46527

    Gene ID:
    1027

    Database links:

    Entrez Gene: 1027 Human

    Entrez Gene: 12576 Mouse

    Entrez Gene: 83571 Rat

    Omim: 600778 Human

    SwissProt: P46527 Human

    Unigene: 238990 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    P27蛋白是一種新發(fā)現(xiàn)的周期素依賴(lài)激酶抑制劑,屬于細(xì)胞周期的負(fù)性調(diào)控因子。P27基因及其產(chǎn)物的異常表達(dá)可能與某些腫瘤的發(fā)生、發(fā)展有著密切的關(guān)系。P27蛋白對(duì)細(xì)胞周期的調(diào)控及在腫瘤中發(fā)揮著很重要的作用。


    久久久久久久久亚洲| 亚洲色成人WWW永久网站| 亚洲激情在线观看| 亚洲精品乱码久久久久久久久久久久 | 无码乱人伦一区二区亚洲一| 国产亚洲日韩在线三区| 亚洲国产专区一区| 亚洲精品国产高清嫩草影院| 亚洲Av无码国产情品久久| 无码专区一va亚洲v专区在线| 无码不卡亚洲成?人片| 国产亚洲综合一区二区三区| 国产亚洲美女精品久久| 国产精品亚洲精品日韩动图| 国产偷国产偷亚洲高清人| 久久亚洲色WWW成人欧美| 国产青草亚洲香蕉精品久久 | 国产精品亚洲片在线观看不卡 | 中文字幕不卡亚洲| 亚洲毛片αv无线播放一区| 亚洲国产成人高清在线观看| 亚洲AV无码国产丝袜在线观看| 久久亚洲国产伦理| 亚洲色偷偷av男人的天堂| 亚洲国产一区在线观看| 亚洲国产视频久久| 亚洲精品日韩一区二区小说| 精品久久久久亚洲| 亚洲欧洲中文日韩久久AV乱码| 亚洲中文字幕成人在线| 亚洲乱码一区二区三区在线观看| 国产精品久久久亚洲| 久久久久亚洲AV无码专区体验| 亚洲精彩视频在线观看| 最新国产成人亚洲精品影院| 亚洲av无码成人精品区一本二本 | 亚洲av无码无线在线观看| 亚洲国产精品无码久久青草| 亚洲无人区一区二区三区| 亚洲精品成人av在线| 亚洲中文字幕久在线|