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磷酸化相關(guān)死亡促進(jìn)因子抗體

產(chǎn)品貨號：

BN41056R
中文名稱：

磷酸化相關(guān)死亡促進(jìn)因子抗體
英文名稱：

Rabbit anti-Phospho-Bad (Ser134) Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN41056R-100ul

100ul

￥2470.00

交叉反應(yīng)：Human 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	Phospho-Bad (Ser134)
中文名稱	磷酸化相關(guān)死亡促進(jìn)因子抗體
別名	Bad (phospho S134); Bad (phospho Ser134); p-Bad (S134);p- Bad (Ser134); p-Bad (phospho Ser134); BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.
產(chǎn)品類型	磷酸化抗體
研究領(lǐng)域	細(xì)胞生物免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡新陳代謝線粒體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human,
產(chǎn)品應(yīng)用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	18kDa
細(xì)胞定位	細(xì)胞漿線粒體
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human BAD around the phosphorylation site of Ser134:PK(p-S)AG
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform. Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Subunit: Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins. Interacts with AKT1 and PIM3. Subcellular Location: Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm. Tissue Specificity: Expressed in a wide variety of tissues. Post-translational modifications: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 andSer-134 in response to survival stimuli, which blocks itspro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75promotes heterodimerization with 14-3-3 proteins. This interactionthen facilitates the phosphorylation at Ser-118, a site within theBH3 motif, leading to the release of Bcl-X(L) and the promotion ofcell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blockedby the apoptotic C-terminus cleavage product of PKN2 generated bycaspases-3 activity during apoptosis. Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99. Similarity: Belongs to the Bcl-2 family. SWISS: Q92934 Gene ID: 572 Database links: Entrez Gene: 572 Human Entrez Gene: 12015 Mouse Entrez Gene: 64639 Rat Omim: 603167 Human SwissProt: Q92934 Human SwissProt: Q61337 Mouse SwissProt: O35147 Rat Unigene: 370254 Human Unigene: 4387 Mouse Unigene: 36696 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BAD是BCL2/BAX,BCL-XL/BAX異二聚體的負(fù)調(diào)節(jié)基因。BAD是BCL2/BCL-XL相關(guān)死亡促進(jìn)因子，作為BCL2, bCL-XL異二聚體伴分子而促進(jìn)細(xì)胞凋亡。