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    磷酸化細(xì)胞角蛋白8抗體
    • 產(chǎn)品貨號(hào):
      BN40953R
    • 中文名稱(chēng):
      磷酸化細(xì)胞角蛋白8抗體
    • 英文名稱(chēng):
      Rabbit anti-phospho-Cytokeratin 8 (Ser23) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

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    • BN40953R-100ul

      100ul

      ¥2470.00

      交叉反應(yīng):Human,Mouse(predicted:Rat) 推薦應(yīng)用:WB,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱(chēng)phospho-Cytokeratin 8 (Ser23)
    中文名稱(chēng)磷酸化細(xì)胞角蛋白8抗體
    別    名Cytokeratin 8 (phospho S23); p-Cytokeratin 8 (phospho S23); card2; Cardiac autoantigen 2 120kD; CK 8; CK-8; ck8; Cyk 8; cyk8; CYKER; Cytokeratin endo A; Cytokeratin-8; Cytokeratin8; DreK8; EndoA; k0; CYK8; k2c8; K2C8_HUMAN; k8; Keratin 8; Keratin type ii cytoskeletal 8; Keratin, type II cytoskeletal 8; Keratin-8; Keratin8; KO; Krt 2.8; Krt 8; krt8; KRT-8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8.  
    產(chǎn)品類(lèi)型磷酸化抗體 
    研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應(yīng)Human, Mouse,  (predicted: Rat, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量53kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthesised phosphopeptide derived from human CK8 around the phosphorylation site of Ser23:SR(p-S)YT 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].

    Function:
    Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

    Subunit:
    Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1.

    Subcellular Location:
    Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

    Tissue Specificity:
    Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

    Post-translational modifications:
    Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
    O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
    O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

    DISEASE:
    Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600].

    Similarity:
    Belongs to the intermediate filament family.

    SWISS:
    P05787

    Gene ID:
    3856

    Database links:

    Entrez Gene: 3856 Human

    Entrez Gene: 16691 Mouse

    Entrez Gene: 25626 Rat

    Omim: 148060 Human

    SwissProt: P05787 Human

    SwissProt: P11679 Mouse

    SwissProt: Q10758 Rat

    Unigene: 533782 Human

    Unigene: 708445 Human

    Unigene: 358618 Mouse

    Unigene: 11083 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    細(xì)胞角蛋白是一類(lèi)與結(jié)構(gòu)相關(guān)的蛋白家族,其在上皮細(xì)胞中形成細(xì)胞骨架中間絲。CK8存在于某些正常腺上皮及其腫瘤,包括許多導(dǎo)管上皮和腺上皮,如結(jié)腸、胃、小腸、氣管的上皮和尿路上皮。CK8主要用于腺癌和導(dǎo)管癌的診斷,該抗體特異識(shí)別第23位絲氨酸磷酸化的CK8。





















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